Detailed information of TA system TA023519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 2242384..2242955
• Replicon: chromosome
• Accession: NC_011979
• Organism: Geobacter daltonii FRC-32

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: GEOB_RS09955
• Protein ID: WP_041267119.1
• Coordinates: 2242384..2242713 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: B9M893
• Locus tag: GEOB_RS09960
• Protein ID: WP_012647088.1
• Coordinates: 2242701..2242955 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEOB_RS09935	2238591..2239619	-	1029	WP_012647083.1	phosphate ABC transporter substrate-binding protein PstS	-
GEOB_RS09940	2239718..2240398	-	681	WP_012647084.1	response regulator transcription factor	-
GEOB_RS09945	2240843..2241025	-	183	WP_012647085.1	hypothetical protein	-
GEOB_RS09950	2241214..2242323	+	1110	WP_012647086.1	M20/M25/M40 family metallo-hydrolase	-
GEOB_RS09955	2242384..2242713	-	330	WP_041267119.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GEOB_RS09960	2242701..2242955	-	255	WP_012647088.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GEOB_RS09965	2243121..2243693	-	573	WP_012647089.1	class I SAM-dependent methyltransferase	-
GEOB_RS09970	2244173..2245408	-	1236	WP_012647090.1	HAF repeat-containing protein	-
GEOB_RS09975	2245993..2247201	-	1209	WP_012647091.1	HAF repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-105)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12306.54 Da
• Isoelectric Point: 9.9007

>T23519 WP_041267119.1 NC_011979:c2242713-2242384 [Geobacter daltonii FRC-32]
MGMVVKRFDVYLVNLDPTVGSEIRKARPCLIISPDEMNRYIATVIVAPMTTKGRDYPTRVTCTFKGKDGQVVLDQIRTVD
KTRLIQRLGKIPKPTQEEVLTILSELFAP

Nucleotide

• Length: 330 bp

>T23519 NC_011979:c2242713-2242384 [Geobacter daltonii FRC-32]
ATGGGAATGGTAGTCAAACGTTTCGATGTTTATCTGGTCAACCTTGACCCGACTGTCGGTAGTGAAATCCGCAAGGCACG
ACCATGCCTCATTATCTCGCCCGACGAAATGAATCGGTATATCGCCACGGTCATCGTTGCGCCGATGACGACCAAAGGCA
GAGATTACCCCACACGAGTGACCTGCACATTCAAGGGCAAGGATGGACAAGTGGTGCTCGATCAAATCAGGACCGTCGAT
AAGACTCGGCTGATTCAGAGACTCGGTAAAATCCCTAAACCGACCCAGGAAGAGGTTTTGACGATTCTTTCTGAACTGTT
TGCCCCGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9742.81 Da
• Isoelectric Point: 4.2290

>AT23519 WP_012647088.1 NC_011979:c2242955-2242701 [Geobacter daltonii FRC-32]
MRTNIIRIGNSQGIRIPKILLEQSNLGTEVDLEVEDEKIIIRSASHPRQGWADAFRLMSESGDDKMVDENLSGQSEWDRD
EWEW

Nucleotide

• Length: 255 bp

>AT23519 NC_011979:c2242955-2242701 [Geobacter daltonii FRC-32]
ATGCGCACAAACATAATTCGAATAGGAAATTCTCAGGGGATTCGGATTCCCAAGATTCTTCTTGAGCAAAGCAATCTGGG
GACCGAAGTAGACCTGGAAGTGGAAGACGAGAAGATCATCATTCGCTCAGCTTCCCACCCAAGGCAGGGGTGGGCCGATG
CATTCAGGCTGATGTCTGAAAGCGGTGACGACAAGATGGTCGATGAGAATTTGAGCGGGCAGTCTGAATGGGACCGGGAT
GAATGGGAATGGTAG

Structures

Antitoxin

• AlphaFold DB: B9M893