Detailed information of TA system TA023517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 107813..109365
• Replicon: chromosome
• Accession: NC_011979
• Organism: Geobacter daltonii FRC-32

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B9M8C4
• Locus tag: GEOB_RS00410
• Protein ID: WP_012645188.1
• Coordinates: 108055..109365 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GEOB_RS00405
• Protein ID: WP_012645187.1
• Coordinates: 107813..108055 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEOB_RS00390	104324..105220	-	897	WP_012645184.1	AraC family transcriptional regulator	-
GEOB_RS00395	105422..106432	+	1011	WP_012645185.1	aldo/keto reductase	-
GEOB_RS00400	106550..107611	+	1062	WP_012645186.1	NAD(P)-dependent alcohol dehydrogenase	-
GEOB_RS00405	107813..108055	+	243	WP_012645187.1	helix-turn-helix domain-containing protein	Antitoxin
GEOB_RS00410	108055..109365	+	1311	WP_012645188.1	type II toxin-antitoxin system HipA family toxin	Toxin
GEOB_RS00415	109844..110569	+	726	WP_012645189.1	twin-arginine translocation signal domain-containing protein	-
GEOB_RS00420	110566..112368	+	1803	WP_012645190.1	aldehyde ferredoxin oxidoreductase family protein	-
GEOB_RS00425	112652..114049	+	1398	WP_012645191.1	hypothetical protein	-
GEOB_RS20020	114093..114242	+	150	WP_154650435.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 48932.25 Da
• Isoelectric Point: 7.5347

>T23517 WP_012645188.1 NC_011979:108055-109365 [Geobacter daltonii FRC-32]
MPRNLAVYLNGTRVGTLTHAARVLQFVYATSWITSSVSRPLSLSMPLRREPYSGDVVENYFDNLLPDNQAIRNRIQTRFG
SPSNRAFDLLWHTGRDCVGAVQLIPDGAEAVDVRRVEATPVSDVKIAAILNNYRTMPLGMRPDIDFRISLAGAQEKTALL
RLDGRWCIPSGVTPTSHILKLPIGTIAHSGMDLTDSVENEWLCHLILKEFGVPVANAEMEVFEGVKALVVERFDRRWAED
GSWLIRLPQEDMCQAMGVAPALKYESDGGPGIQKIMTFLLGSADALGDRRVFMQVQVLFWLLAAIDGHAKNFSIFIRPRG
EFSLTPMYDVLSAYPLVVKGQLDPHRLRMAMAVSGKNRRYEHISIRYRHWLATAQRNNVSPEEMALIIEELLDRVDSITA
AVASRLPHNFPGDVAESIFEGMRQSRDRLASQKHER

Nucleotide

• Length: 1311 bp

>T23517 NC_011979:108055-109365 [Geobacter daltonii FRC-32]
ATGCCCAGGAATCTAGCGGTTTACCTTAATGGGACCAGGGTAGGAACTTTGACTCATGCTGCCAGAGTGCTTCAGTTCGT
TTATGCTACCTCCTGGATTACCTCCAGCGTGAGCCGTCCCCTCTCACTTTCAATGCCCCTTCGGAGGGAGCCCTATTCAG
GGGACGTCGTCGAGAATTACTTCGATAACTTGCTTCCTGACAATCAGGCGATCAGGAATCGTATCCAGACAAGATTTGGT
TCTCCGTCAAACCGTGCATTTGATCTTTTGTGGCATACCGGCCGTGATTGCGTCGGTGCAGTTCAATTGATACCAGACGG
TGCTGAGGCTGTAGATGTTAGAAGGGTAGAAGCTACTCCTGTATCGGACGTAAAGATAGCGGCCATCCTTAACAATTATC
GGACAATGCCGTTGGGTATGCGACCGGATATTGACTTCCGAATCTCGCTGGCAGGCGCGCAGGAGAAGACGGCTTTGCTC
CGGCTTGATGGCAGGTGGTGCATCCCCTCGGGGGTGACTCCAACAAGTCACATCCTGAAGCTTCCGATCGGAACGATTGC
CCATAGTGGTATGGACCTCACTGATAGTGTCGAGAATGAATGGCTTTGTCACCTCATTCTGAAGGAATTTGGTGTTCCGG
TCGCCAATGCGGAAATGGAAGTCTTTGAAGGGGTGAAGGCTCTTGTGGTAGAGCGATTCGACCGACGCTGGGCTGAGGAT
GGCTCGTGGTTGATTCGACTTCCACAAGAGGACATGTGCCAGGCGATGGGAGTGGCGCCCGCATTGAAATATGAGAGTGA
TGGAGGCCCCGGCATCCAGAAGATCATGACTTTTTTGCTCGGATCGGCAGACGCGCTGGGTGACCGGCGGGTATTTATGC
AGGTGCAGGTACTTTTCTGGCTTCTGGCTGCAATCGATGGCCATGCCAAGAACTTCAGCATCTTTATACGCCCGCGTGGC
GAGTTTTCCCTAACCCCGATGTATGATGTGCTTTCCGCATATCCTCTTGTAGTAAAGGGACAACTAGATCCACACAGGTT
GAGAATGGCGATGGCTGTCAGTGGCAAAAACCGTCGATATGAGCACATCTCCATCCGCTACAGGCATTGGCTGGCAACGG
CTCAGAGAAATAACGTATCGCCTGAGGAAATGGCGCTGATAATTGAGGAGCTCCTTGATCGGGTGGACAGCATAACCGCA
GCTGTGGCTTCCAGATTGCCCCATAATTTCCCTGGAGATGTCGCTGAAAGCATCTTTGAAGGGATGCGGCAGTCTCGAGA
TAGGTTGGCGTCGCAGAAACACGAACGCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8848.31 Da
• Isoelectric Point: 10.5649

>AT23517 WP_012645187.1 NC_011979:107813-108055 [Geobacter daltonii FRC-32]
MSGIRSPKELGEALRQKRKAKGLTQTAAGKPVNLVQSKISQIENGTLAIELSTLFRLLAALDLELVVQPRQKHEIKGDEW

Nucleotide

• Length: 243 bp

>AT23517 NC_011979:107813-108055 [Geobacter daltonii FRC-32]
ATGAGCGGAATTCGTTCTCCAAAAGAACTAGGGGAGGCACTTCGCCAGAAACGTAAGGCAAAGGGGTTGACACAGACGGC
TGCAGGGAAGCCGGTTAACCTGGTGCAATCCAAAATATCGCAGATCGAAAACGGAACCCTTGCCATCGAGTTGAGTACCC
TATTCCGACTTCTGGCGGCACTTGACCTGGAGCTGGTGGTACAGCCACGACAAAAGCATGAAATTAAAGGAGATGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: B9M8C4