Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1232044..1232489 Replicon chromosome
Accession NC_011978
Organism Thermotoga neapolitana DSM 4359

Toxin (Protein)


Gene name hicA Uniprot ID D2C4B8
Locus tag CTN_RS06365 Protein ID WP_008195297.1
Coordinates 1232259..1232489 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID Q9X145
Locus tag CTN_RS06360 Protein ID WP_004083352.1
Coordinates 1232044..1232262 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTN_RS06350 1228357..1229748 - 1392 WP_004083362.1 radical SAM protein -
CTN_RS09815 1229850..1229945 - 96 WP_010865309.1 Cys-rich RiPP peptide -
CTN_RS09940 1230022..1230186 - 165 WP_004083364.1 hypothetical protein -
CTN_RS06355 1230382..1232031 + 1650 WP_015919755.1 helix-turn-helix domain-containing protein -
CTN_RS06360 1232044..1232262 + 219 WP_004083352.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CTN_RS06365 1232259..1232489 + 231 WP_008195297.1 type II toxin-antitoxin system HicA family toxin Toxin
CTN_RS06370 1232512..1232724 + 213 WP_004079908.1 hypothetical protein -
CTN_RS09730 1232714..1232863 + 150 WP_081434644.1 type II toxin-antitoxin system HicA family toxin -
CTN_RS06375 1232934..1234676 - 1743 WP_004079909.1 ABC transporter ATP-binding protein/permease -
CTN_RS06380 1234739..1235509 - 771 WP_011943918.1 ABC transporter permease -
CTN_RS06385 1235513..1235947 - 435 WP_004079914.1 ABC transporter permease -
CTN_RS06390 1236165..1236971 - 807 WP_004079915.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1212840..1240840 28000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-57)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8881.54 Da        Isoelectric Point: 11.0394

>T23516 WP_008195297.1 NC_011978:1232259-1232489 [Thermotoga neapolitana DSM 4359]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGRYTTIPFHARALPKSLIRKIIREAGISVEEFKKVLENL

Download         Length: 231 bp

>T23516 NC_011978:1232259-1232489 [Thermotoga neapolitana DSM 4359]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGCAGATATACGACCATCCCATTTCATGCAAGAGCCTTGCCCAAATCAC
TTATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8215.35 Da        Isoelectric Point: 4.0887

>AT23516 WP_004083352.1 NC_011978:1232044-1232262 [Thermotoga neapolitana DSM 4359]
MRKIFTAIIEYDPETKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINHQEFVALEMIEVET

Download         Length: 219 bp

>AT23516 NC_011978:1232044-1232262 [Thermotoga neapolitana DSM 4359]
ATGCGTAAAATTTTCACAGCTATCATTGAATACGATCCTGAAACAAAGCAATATGTTGGAATGGTTCCGGACGTTCCGGG
TGTGCATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCACCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5L026

Antitoxin

Source ID Structure
AlphaFold DB A0A0A6N0B1

References