235157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2613294..2613988 Replicon chromosome
Accession NZ_CP091901
Organism Enterococcus faecalis strain 59

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag L5I17_RS12735 Protein ID WP_033781500.1
Coordinates 2613644..2613988 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag L5I17_RS12730 Protein ID WP_016626775.1
Coordinates 2613294..2613626 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5I17_RS12680 (2609519) 2609519..2609749 - 231 WP_202569672.1 hypothetical protein -
L5I17_RS12685 (2609806) 2609806..2609961 - 156 WP_174098227.1 hypothetical protein -
L5I17_RS15830 (2609946) 2609946..2610071 - 126 WP_258143643.1 hypothetical protein -
L5I17_RS12690 (2610068) 2610068..2610241 - 174 WP_002364664.1 hypothetical protein -
L5I17_RS12695 (2610253) 2610253..2610438 - 186 WP_002364665.1 hypothetical protein -
L5I17_RS12700 (2610449) 2610449..2611159 - 711 WP_238468086.1 Rha family transcriptional regulator -
L5I17_RS12705 (2611237) 2611237..2611686 + 450 WP_102990646.1 hypothetical protein -
L5I17_RS12710 (2611833) 2611833..2611973 - 141 WP_002404537.1 hypothetical protein -
L5I17_RS12715 (2612012) 2612012..2612281 - 270 WP_113813751.1 hypothetical protein -
L5I17_RS12720 (2612357) 2612357..2612671 + 315 WP_010776102.1 hypothetical protein -
L5I17_RS15835 (2612652) 2612652..2612780 - 129 WP_010776103.1 hypothetical protein -
L5I17_RS12725 (2612796) 2612796..2612972 - 177 WP_113813753.1 helix-turn-helix transcriptional regulator -
L5I17_RS12730 (2613294) 2613294..2613626 + 333 WP_016626775.1 helix-turn-helix transcriptional regulator Antitoxin
L5I17_RS12735 (2613644) 2613644..2613988 + 345 WP_033781500.1 ImmA/IrrE family metallo-endopeptidase Toxin
L5I17_RS12740 (2614013) 2614013..2614246 - 234 WP_002367290.1 hypothetical protein -
L5I17_RS12745 (2614336) 2614336..2615019 + 684 WP_129194668.1 hypothetical protein -
L5I17_RS12750 (2615196) 2615196..2616377 + 1182 WP_202569674.1 site-specific integrase -
L5I17_RS12755 (2616480) 2616480..2616629 - 150 WP_002356321.1 50S ribosomal protein L33 -
L5I17_RS12760 (2616755) 2616755..2618893 - 2139 WP_002356320.1 penicillin-binding transpeptidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2594887..2616377 21490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-61)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13610.61 Da        Isoelectric Point: 5.6177

>T235157 WP_033781500.1 NZ_CP091901:2613644-2613988 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

>T235157 NZ_LR134222:c2460798-2460622 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12547.24 Da        Isoelectric Point: 5.2423

>AT235157 WP_016626775.1 NZ_CP091901:2613294-2613626 [Enterococcus faecalis]
MTAFDRIKKITDRKGISINELENRVGISQNVLYGWKKKTPGGENLTKVAKYLNISTDYILGIVDNPEPFVEKKTDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT235157 NZ_LR134222:c2460576-2460160 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References