23515

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3456818..3457406 Replicon chromosome
Accession NC_011916
Organism Caulobacter crescentus NA1000

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3CEH8
Locus tag CCNA_03288 Protein ID YP_002518660.1
Coordinates 3456818..3457006 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3CB85
Locus tag CCNA_03289 Protein ID YP_002518661.1
Coordinates 3457011..3457406 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCNA_03283 3452702..3453721 - 1020 YP_002518655.2 TIM-barrel metal-dependent hydrolase -
CCNA_03284 3453897..3454931 + 1035 YP_002518656.1 adenosine deaminase -
CCNA_03285 3454942..3455910 + 969 YP_002518657.1 magnesium and cobalt transport protein CorA -
CCNA_03286 3455888..3456568 - 681 YP_002518658.1 hypothetical protein -
CCNA_03287 3456436..3456741 - 306 YP_002518659.1 PadR-family transcriptional regulator -
CCNA_03288 3456818..3457006 + 189 YP_002518660.1 type II toxin-antitoxin system HicA family toxin Toxin
CCNA_03289 3457011..3457406 + 396 YP_002518661.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CCNA_03290 3457415..3457891 - 477 YP_002518662.1 DUF2199 domain-containing protein -
CCNA_03291 3457949..3458947 - 999 YP_002518663.1 WecE-family pyridoxal phosphate-dependent enzyme -
CCNA_03292 3459075..3460628 - 1554 YP_002518664.2 long-chain-fatty-acid--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6984.02 Da        Isoelectric Point: 11.4778

>T23515 YP_002518660.1 NC_011916:3456818-3457006 [Caulobacter vibrioides NA1000]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR

Download         Length: 189 bp

>T23515 NC_011916:3456818-3457006 [Caulobacter vibrioides NA1000]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCAACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGTGACTTGCCGCTAGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13937.84 Da        Isoelectric Point: 4.1587

>AT23515 YP_002518661.1 NC_011916:3457011-3457406 [Caulobacter vibrioides NA1000]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA

Download         Length: 396 bp

>AT23515 NC_011916:3457011-3457406 [Caulobacter vibrioides NA1000]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCCCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3CEH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3CB85

References