Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_26(antitoxin) |
| Location | 2537229..2537927 | Replicon | chromosome |
| Accession | NZ_CP091899 | ||
| Organism | Enterococcus faecalis strain 101-1 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | A0A059N529 |
| Locus tag | L5I21_RS12440 | Protein ID | WP_002373917.1 |
| Coordinates | 2537583..2537927 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | L5I21_RS12435 | Protein ID | WP_002388206.1 |
| Coordinates | 2537229..2537564 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I21_RS12380 (2532445) | 2532445..2533260 | - | 816 | WP_010706853.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
| L5I21_RS12385 (2533223) | 2533223..2534194 | - | 972 | WP_010706854.1 | RecT family recombinase | - |
| L5I21_RS12390 (2534287) | 2534287..2534643 | - | 357 | WP_010706855.1 | hypothetical protein | - |
| L5I21_RS12395 (2534646) | 2534646..2534870 | - | 225 | WP_002367281.1 | hypothetical protein | - |
| L5I21_RS12400 (2534867) | 2534867..2535166 | - | 300 | WP_010706856.1 | hypothetical protein | - |
| L5I21_RS12405 (2535253) | 2535253..2535669 | - | 417 | WP_002417286.1 | hypothetical protein | - |
| L5I21_RS12410 (2535670) | 2535670..2535840 | - | 171 | WP_010706857.1 | hypothetical protein | - |
| L5I21_RS12415 (2535875) | 2535875..2536144 | - | 270 | WP_002365131.1 | hypothetical protein | - |
| L5I21_RS12420 (2536162) | 2536162..2536341 | - | 180 | WP_229202013.1 | DUF2829 domain-containing protein | - |
| L5I21_RS12425 (2536404) | 2536404..2536742 | - | 339 | WP_010706859.1 | hypothetical protein | - |
| L5I21_RS12430 (2536755) | 2536755..2536937 | - | 183 | WP_002388205.1 | hypothetical protein | - |
| L5I21_RS12435 (2537229) | 2537229..2537564 | + | 336 | WP_002388206.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L5I21_RS12440 (2537583) | 2537583..2537927 | + | 345 | WP_002373917.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| L5I21_RS12445 (2537956) | 2537956..2538354 | + | 399 | WP_010706860.1 | hypothetical protein | - |
| L5I21_RS12450 (2538372) | 2538372..2539103 | + | 732 | WP_010706861.1 | potassium channel family protein | - |
| L5I21_RS12455 (2539258) | 2539258..2540439 | + | 1182 | WP_002365138.1 | site-specific integrase | - |
| L5I21_RS12460 (2540542) | 2540542..2540691 | - | 150 | WP_002356321.1 | 50S ribosomal protein L33 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2499043..2540439 | 41396 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13594.61 Da Isoelectric Point: 5.6177
>T235127 WP_002373917.1 NZ_CP091899:2537583-2537927 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
Download Length: 345 bp
>T235127 NZ_LR134216:3635100-3635378 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12842.51 Da Isoelectric Point: 5.2926
>AT235127 WP_002388206.1 NZ_CP091899:2537229-2537564 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
Download Length: 336 bp
>AT235127 NZ_LR134216:3634837-3635097 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|