235113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1816100..1816793 Replicon chromosome
Accession NZ_CP091897
Organism Enterococcus faecalis strain 119-1

Toxin (Protein)


Gene name IrrE Uniprot ID S4BLV4
Locus tag L5I23_RS08940 Protein ID WP_002378467.1
Coordinates 1816449..1816793 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag L5I23_RS08935 Protein ID WP_002364355.1
Coordinates 1816100..1816432 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5I23_RS08890 (1811572) 1811572..1812306 - 735 WP_002378463.1 ERF family protein -
L5I23_RS08895 (1812299) 1812299..1812616 - 318 WP_002357007.1 hypothetical protein -
L5I23_RS08900 (1812836) 1812836..1813390 + 555 WP_002357006.1 hypothetical protein -
L5I23_RS08905 (1813817) 1813817..1814011 - 195 WP_002378464.1 hypothetical protein -
L5I23_RS08910 (1814048) 1814048..1814257 - 210 WP_002378465.1 hypothetical protein -
L5I23_RS08915 (1814312) 1814312..1814500 + 189 WP_002357001.1 YegP family protein -
L5I23_RS08920 (1814526) 1814526..1815251 - 726 WP_002378466.1 phage regulatory protein -
L5I23_RS08925 (1815290) 1815290..1815601 - 312 WP_002381719.1 hypothetical protein -
L5I23_RS08930 (1815612) 1815612..1815788 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
L5I23_RS08935 (1816100) 1816100..1816432 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
L5I23_RS08940 (1816449) 1816449..1816793 + 345 WP_002378467.1 ImmA/IrrE family metallo-endopeptidase Toxin
L5I23_RS08945 (1816829) 1816829..1817557 + 729 WP_002378468.1 potassium channel family protein -
L5I23_RS08950 (1817657) 1817657..1818805 + 1149 WP_002378469.1 site-specific integrase -
L5I23_RS08955 (1818842) 1818842..1819276 - 435 Protein_1736 competence type IV pilus minor pilin ComGD -
L5I23_RS08960 (1819273) 1819273..1819548 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
L5I23_RS08965 (1819548) 1819548..1820594 - 1047 WP_002369171.1 competence type IV pilus assembly protein ComGB -
L5I23_RS08970 (1820551) 1820551..1821519 - 969 WP_002364362.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1779762..1819249 39487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13712.62 Da        Isoelectric Point: 5.5523

>T235113 WP_002378467.1 NZ_CP091897:1816449-1816793 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

>T235113 NZ_LR134216:182015-182122 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT235113 WP_002364355.1 NZ_CP091897:1816100-1816432 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT235113 NZ_LR134216:c181967-181901 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BLV4

Antitoxin

Source ID Structure

References