Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 1517687..1518824 | Replicon | chromosome |
| Accession | NZ_CP091897 | ||
| Organism | Enterococcus faecalis strain 119-1 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | L5I23_RS07330 | Protein ID | WP_002401483.1 |
| Coordinates | 1517687..1518550 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | R2XCR7 |
| Locus tag | L5I23_RS07335 | Protein ID | WP_000301765.1 |
| Coordinates | 1518552..1518824 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I23_RS07295 (1512893) | 1512893..1513756 | - | 864 | WP_002382350.1 | DNA-processing protein DprA | - |
| L5I23_RS07300 (1513817) | 1513817..1514584 | - | 768 | WP_002357481.1 | ribonuclease HII | - |
| L5I23_RS07305 (1514586) | 1514586..1515437 | - | 852 | WP_002357480.1 | ribosome biogenesis GTPase YlqF | - |
| L5I23_RS07310 (1515713) | 1515713..1515829 | - | 117 | Protein_1410 | ketopantoate reductase C-terminal domain-containing protein | - |
| L5I23_RS07315 (1515884) | 1515884..1516564 | - | 681 | WP_010713039.1 | IS6-like element IS1216 family transposase | - |
| L5I23_RS07320 (1516640) | 1516640..1516909 | - | 270 | Protein_1412 | DnaJ domain-containing protein | - |
| L5I23_RS07325 (1516929) | 1516929..1517246 | - | 318 | WP_002333463.1 | hypothetical protein | - |
| L5I23_RS07330 (1517687) | 1517687..1518550 | - | 864 | WP_002401483.1 | zeta toxin family protein | Toxin |
| L5I23_RS07335 (1518552) | 1518552..1518824 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
| L5I23_RS07340 (1518841) | 1518841..1519056 | - | 216 | WP_002295735.1 | peptide-binding protein | - |
| L5I23_RS07345 (1519155) | 1519155..1520051 | - | 897 | WP_002387620.1 | ParA family protein | - |
| L5I23_RS07350 (1520154) | 1520154..1520414 | - | 261 | Protein_1418 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| L5I23_RS07355 (1520584) | 1520584..1521321 | - | 738 | WP_002292226.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| L5I23_RS07360 (1521446) | 1521446..1521529 | - | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| L5I23_RS07365 (1521578) | 1521578..1521817 | - | 240 | WP_000635249.1 | peptide-binding protein | - |
| L5I23_RS07370 (1521951) | 1521951..1523477 | - | 1527 | WP_025191980.1 | type IA DNA topoisomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | erm(B) / aph(3')-III / ant(6)-Ia / aac(6')-aph(2'') | - | 1515884..1536003 | 20119 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32486.06 Da Isoelectric Point: 6.9965
>T235112 WP_002401483.1 NZ_CP091897:c1518550-1517687 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
Download Length: 864 bp
>T235112 NZ_LR134215:3145950-3146303 [Shimwellia blattae]
ATGTGGACTGTATTTTTTGGGCCAGTTTTTGATGCCTGGTTTGAAGAGCAAGAGCCCGCACTGAAGGAAAAAGTGTTAGC
CAACCTGCGCAATCTGGAAAAGTACGGTCCTTCTCTTTCCCGGCCATATGCGGATACCGTTTATGGCTCACGATATAAAA
ACATGAAGGAGTTGCGCATTCAGTATTCCGGATACCCTGTCCGGGCATTTTTTGCGTTTGATCCGGTTCGCCGTGCCATT
GTGCTTTGCGCCGGTGATAAAAGTAATGACAAAAAGTTTTACGACAGAATGATCCGCATTGCTGACGACGAGTTTTCCGC
TCACCTTGCAACGTTGGAGGGTAGTACGAAATGA
ATGTGGACTGTATTTTTTGGGCCAGTTTTTGATGCCTGGTTTGAAGAGCAAGAGCCCGCACTGAAGGAAAAAGTGTTAGC
CAACCTGCGCAATCTGGAAAAGTACGGTCCTTCTCTTTCCCGGCCATATGCGGATACCGTTTATGGCTCACGATATAAAA
ACATGAAGGAGTTGCGCATTCAGTATTCCGGATACCCTGTCCGGGCATTTTTTGCGTTTGATCCGGTTCGCCGTGCCATT
GTGCTTTGCGCCGGTGATAAAAGTAATGACAAAAAGTTTTACGACAGAATGATCCGCATTGCTGACGACGAGTTTTCCGC
TCACCTTGCAACGTTGGAGGGTAGTACGAAATGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT235112 WP_000301765.1 NZ_CP091897:c1518824-1518552 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT235112 NZ_LR134215:3146300-3146599 [Shimwellia blattae]
ATGAGAACACTAAAAGAAGTCATTGCCGCCCAGACGCCTGAGAGCCAGGCCCGCATTAACGAAATGGCCGAAGAGATGAT
TTTAGAAACGGGCCTCCAGATGATGCGTGAGGAGCTGCAGCTATCCCAGAAGGCGGTGGCCGACGCAATGGGCATCCGGC
AGCCTGCCATTACACAGATTGAACAACGCGGGAATGATATCAAACTGGCCACGCTCAAACGCTATATTGAGGCCATGGGG
GGTAAACTGAGCCTTGATGTTGAGTTGCCGACCGGTAAACGGATAGCTTTTCACATCTAA
ATGAGAACACTAAAAGAAGTCATTGCCGCCCAGACGCCTGAGAGCCAGGCCCGCATTAACGAAATGGCCGAAGAGATGAT
TTTAGAAACGGGCCTCCAGATGATGCGTGAGGAGCTGCAGCTATCCCAGAAGGCGGTGGCCGACGCAATGGGCATCCGGC
AGCCTGCCATTACACAGATTGAACAACGCGGGAATGATATCAAACTGGCCACGCTCAAACGCTATATTGAGGCCATGGGG
GGTAAACTGAGCCTTGATGTTGAGTTGCCGACCGGTAAACGGATAGCTTTTCACATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|