23511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 994709..995262 Replicon chromosome
Accession NC_011916
Organism Caulobacter crescentus NA1000

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3C6T0
Locus tag CCNA_00916 Protein ID YP_002516289.1
Coordinates 994709..994999 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H3C849
Locus tag CCNA_00917 Protein ID YP_002516290.1
Coordinates 994996..995262 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCNA_00910 990076..991266 - 1191 YP_002516283.1 erythromycin esterase family protein -
CCNA_00911 991329..991919 - 591 YP_002516284.1 AAA domain ATPase -
CCNA_00912 991916..992983 - 1068 YP_002516285.1 beta-lactamase family protein -
CCNA_00913 993033..993209 - 177 YP_002516286.1 hypothetical protein -
CCNA_00914 993288..993815 - 528 YP_002516287.1 acetyltransferase -
CCNA_00915 993947..994708 + 762 YP_002516288.2 Molybdenum cofactor sulfurase related protein -
CCNA_00916 994709..994999 - 291 YP_002516289.1 toxin protein parE1 Toxin
CCNA_00917 994996..995262 - 267 YP_002516290.1 antitoxin protein parD1 Antitoxin
CCNA_00918 995336..996205 + 870 YP_002516291.1 peptide release factor-glutamine N5-methyltransferase -
CCNA_00919 996243..996467 + 225 YP_002516292.1 hypothetical protein -
CCNA_00920 996464..997576 + 1113 YP_002516293.1 hypothetical protein -
CCNA_00921 997744..998499 + 756 YP_002516294.1 zinc metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(2-81)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11057.55 Da        Isoelectric Point: 8.9111

>T23511 YP_002516289.1 NC_011916:c994999-994709 [Caulobacter vibrioides NA1000]
MKPYRLSRRAKADLDDIWTYSEQRWGVEQAADYARELQATIEMIAEHPGMGQPDENLRAGYRRCASGSHVVFYRVGVRVE
IIRVLHQSMNARAHLG

Download         Length: 291 bp

>T23511 NC_011916:c994999-994709 [Caulobacter vibrioides NA1000]
ATGAAGCCCTATCGGCTATCCCGTCGCGCCAAGGCCGACCTCGATGACATCTGGACCTATTCAGAGCAGCGATGGGGCGT
TGAACAAGCCGCCGACTACGCCCGTGAACTGCAGGCCACCATCGAGATGATCGCTGAACATCCGGGTATGGGACAGCCGG
ATGAAAACCTCCGCGCGGGCTACAGGCGATGCGCCAGCGGCTCGCACGTGGTCTTTTACCGCGTCGGCGTGCGGGTCGAG
ATTATCCGCGTGCTACACCAAAGCATGAACGCCAGGGCTCACCTTGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9635.57 Da        Isoelectric Point: 4.1523

>AT23511 YP_002516290.1 NC_011916:c995262-994996 [Caulobacter vibrioides NA1000]
MASKNTSVVLGDHFQAFIDSQVADGRYGSASEVIRAGLRLLEENEAKLAALRAALIEGEESGFIEDFDFDAFIEERSRAS
APQGFHEE

Download         Length: 267 bp

>AT23511 NC_011916:c995262-994996 [Caulobacter vibrioides NA1000]
ATGGCGAGCAAGAACACCTCCGTCGTCCTGGGCGATCACTTCCAGGCGTTCATCGACAGCCAGGTCGCTGACGGGCGCTA
CGGCTCGGCCAGCGAAGTCATCCGCGCGGGGCTGAGGCTCCTCGAAGAGAACGAAGCGAAGCTCGCGGCCCTCCGCGCCG
CCCTGATCGAAGGCGAGGAGAGCGGCTTTATCGAGGACTTCGACTTCGACGCCTTTATCGAGGAAAGGTCTAGGGCATCC
GCTCCGCAGGGGTTCCATGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3C6T0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3C849

References