Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-DinJ |
| Location | 391924..392458 | Replicon | chromosome |
| Accession | NZ_CP091897 | ||
| Organism | Enterococcus faecalis strain 119-1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | R3JX52 |
| Locus tag | L5I23_RS02000 | Protein ID | WP_002360769.1 |
| Coordinates | 392183..392458 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | R3H6P0 |
| Locus tag | L5I23_RS01995 | Protein ID | WP_002369771.1 |
| Coordinates | 391924..392190 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I23_RS01960 (387974) | 387974..388567 | + | 594 | WP_002414802.1 | replication-relaxation family protein | - |
| L5I23_RS01965 (388573) | 388573..389061 | + | 489 | WP_010710133.1 | hypothetical protein | - |
| L5I23_RS01970 (389653) | 389653..389919 | + | 267 | WP_002377947.1 | hypothetical protein | - |
| L5I23_RS01975 (389952) | 389952..390452 | + | 501 | WP_002360775.1 | DnaJ domain-containing protein | - |
| L5I23_RS01980 (390465) | 390465..390713 | + | 249 | WP_002360773.1 | DUF3850 domain-containing protein | - |
| L5I23_RS01985 (390789) | 390789..391205 | + | 417 | WP_010710134.1 | single-stranded DNA-binding protein | - |
| L5I23_RS01990 (391229) | 391229..391813 | + | 585 | WP_002377949.1 | thermonuclease family protein | - |
| L5I23_RS01995 (391924) | 391924..392190 | + | 267 | WP_002369771.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| L5I23_RS02000 (392183) | 392183..392458 | + | 276 | WP_002360769.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| L5I23_RS02005 (392649) | 392649..393293 | - | 645 | WP_002377952.1 | IS6 family transposase | - |
| L5I23_RS02010 (393426) | 393426..394308 | + | 883 | Protein_372 | IS256 family transposase | - |
| L5I23_RS02015 (394613) | 394613..395650 | - | 1038 | WP_002355369.1 | PTS sugar transporter subunit IIC | - |
| L5I23_RS02020 (395676) | 395676..396614 | - | 939 | WP_002370935.1 | 2-dehydropantoate 2-reductase | - |
| L5I23_RS02025 (396742) | 396742..397071 | - | 330 | WP_002358661.1 | LPXTG cell wall anchor domain-containing protein | - |
| L5I23_RS02030 (397101) | 397101..397286 | + | 186 | WP_002358660.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | bsh / cylR2 / cylR1 / cylL / cylS / cylM / cylB / cylA / cylI / esp | 370834..429978 | 59144 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10732.58 Da Isoelectric Point: 9.6918
>T235108 WP_002360769.1 NZ_CP091897:392183-392458 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
Download Length: 276 bp
>T235108 NZ_LR134215:1894431-1894913 [Shimwellia blattae]
ATGGAAATAAATGTTACGGCACCGGCGTTACTGACTGAAGATCATATTCTTCAGCCATTTGATTGCGGGAATGACATTCT
AAGCGATTGGTTACGCCGCCGGGCAATAAAAAATCAGCACCTTAATGCATCACGCACGTTTGTTATCTGTCTGGAAGGGA
CAAAACGTGTGGTCGGTTATTACTCCATTGCAACGGGCTCTGTGAGTCATATCGATTTAGGCCGCAGCTTGCGAAAGAAT
ATGCCTGATCCTGTTCCCGTCGTGTTATTGGGGCGGCTGGCTGTCGATGTCTGTACTCAGGGAAATAGCTTTGGGAAATG
GATGTTAAATGATGCCGTGATGAGAGTCTCTAACCTGGCAGACCAGGTCGGAATTAAAGCTATCATGGTGCATGCTATTA
ACGATGAGGCAAAAGCGTTCTATGAGCATTTCGGTTTTGTCCAGTCCCCTTTGACCCCCAGGACACTCTTTTTCAAAATA
TAA
ATGGAAATAAATGTTACGGCACCGGCGTTACTGACTGAAGATCATATTCTTCAGCCATTTGATTGCGGGAATGACATTCT
AAGCGATTGGTTACGCCGCCGGGCAATAAAAAATCAGCACCTTAATGCATCACGCACGTTTGTTATCTGTCTGGAAGGGA
CAAAACGTGTGGTCGGTTATTACTCCATTGCAACGGGCTCTGTGAGTCATATCGATTTAGGCCGCAGCTTGCGAAAGAAT
ATGCCTGATCCTGTTCCCGTCGTGTTATTGGGGCGGCTGGCTGTCGATGTCTGTACTCAGGGAAATAGCTTTGGGAAATG
GATGTTAAATGATGCCGTGATGAGAGTCTCTAACCTGGCAGACCAGGTCGGAATTAAAGCTATCATGGTGCATGCTATTA
ACGATGAGGCAAAAGCGTTCTATGAGCATTTCGGTTTTGTCCAGTCCCCTTTGACCCCCAGGACACTCTTTTTCAAAATA
TAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9772.09 Da Isoelectric Point: 4.4791
>AT235108 WP_002369771.1 NZ_CP091897:391924-392190 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
Download Length: 267 bp
>AT235108 NZ_LR134215:1894156-1894440 [Shimwellia blattae]
ATGCACACGACTATCCGGAAAGCCACCCGGGATAAGCAGATCAATATCCGGGCTACAGAGGAAGAGCGGGCCGTGATTGA
CTATGCGGCGAGCCTGCTTAACAAAAATCGGACCGATTTCATCATTGAACAGGCGGTGAGTGAGGCGCAAAACATCATCC
TGGATCAGCGTGTTTTTGCCCTGGATGACGCCCGTTATCAGGCGTTTATTGAGCAACTTGAAGGGCCTGTTCAGAATGAA
GAAGGCCGTCAGCGTTTGCTGGATGTGAAGCCCGAATGGAAATAA
ATGCACACGACTATCCGGAAAGCCACCCGGGATAAGCAGATCAATATCCGGGCTACAGAGGAAGAGCGGGCCGTGATTGA
CTATGCGGCGAGCCTGCTTAACAAAAATCGGACCGATTTCATCATTGAACAGGCGGTGAGTGAGGCGCAAAACATCATCC
TGGATCAGCGTGTTTTTGCCCTGGATGACGCCCGTTATCAGGCGTTTATTGAGCAACTTGAAGGGCCTGTTCAGAATGAA
GAAGGCCGTCAGCGTTTGCTGGATGTGAAGCCCGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2AEA7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2AED7 |