Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 1805396..1806089 | Replicon | chromosome |
| Accession | NZ_CP091895 | ||
| Organism | Enterococcus faecalis strain 119-2 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | S4BLV4 |
| Locus tag | L5I25_RS08860 | Protein ID | WP_002378467.1 |
| Coordinates | 1805745..1806089 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | L5I25_RS08855 | Protein ID | WP_002364355.1 |
| Coordinates | 1805396..1805728 (+) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I25_RS08810 (1800868) | 1800868..1801602 | - | 735 | WP_002378463.1 | ERF family protein | - |
| L5I25_RS08815 (1801595) | 1801595..1801912 | - | 318 | WP_002357007.1 | hypothetical protein | - |
| L5I25_RS08820 (1802132) | 1802132..1802686 | + | 555 | WP_002357006.1 | hypothetical protein | - |
| L5I25_RS08825 (1803113) | 1803113..1803307 | - | 195 | WP_002378464.1 | hypothetical protein | - |
| L5I25_RS08830 (1803344) | 1803344..1803553 | - | 210 | WP_002378465.1 | hypothetical protein | - |
| L5I25_RS08835 (1803608) | 1803608..1803796 | + | 189 | WP_002357001.1 | YegP family protein | - |
| L5I25_RS08840 (1803822) | 1803822..1804547 | - | 726 | WP_002378466.1 | phage regulatory protein | - |
| L5I25_RS08845 (1804586) | 1804586..1804897 | - | 312 | WP_002381719.1 | hypothetical protein | - |
| L5I25_RS08850 (1804908) | 1804908..1805084 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| L5I25_RS08855 (1805396) | 1805396..1805728 | + | 333 | WP_002364355.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L5I25_RS08860 (1805745) | 1805745..1806089 | + | 345 | WP_002378467.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| L5I25_RS08865 (1806125) | 1806125..1806853 | + | 729 | WP_002378468.1 | potassium channel family protein | - |
| L5I25_RS08870 (1806953) | 1806953..1808101 | + | 1149 | WP_002378469.1 | site-specific integrase | - |
| L5I25_RS08875 (1808138) | 1808138..1808572 | - | 435 | Protein_1720 | competence type IV pilus minor pilin ComGD | - |
| L5I25_RS08880 (1808569) | 1808569..1808844 | - | 276 | WP_002356991.1 | competence type IV pilus major pilin ComGC | - |
| L5I25_RS08885 (1808844) | 1808844..1809890 | - | 1047 | WP_002369171.1 | competence type IV pilus assembly protein ComGB | - |
| L5I25_RS08890 (1809847) | 1809847..1810815 | - | 969 | WP_002364362.1 | competence type IV pilus ATPase ComGA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1759669..1808545 | 48876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13712.62 Da Isoelectric Point: 5.5523
>T235096 WP_002378467.1 NZ_CP091895:1805745-1806089 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
Download Length: 345 bp
>T235096 NZ_LR134214:c2369233-2368955 [Citrobacter portucalensis]
ATGATCATGAACTTCAGGCACAAGGGATTGCGCGATTTGTTTCTTCATGGACGAACATCGGGCGTTATGGCGAAACATGT
CCGACGATTACGACACAGACTTGCCGTTATTGATGCGGCAAGCAAGGTTACAGATATCAATATGCCTGGTTATAAGCTAC
ATCCTCTGGTGGGTGAACGCGACGGCATATGGGCAATTTCTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGATTACGAGGACTATCATTGA
ATGATCATGAACTTCAGGCACAAGGGATTGCGCGATTTGTTTCTTCATGGACGAACATCGGGCGTTATGGCGAAACATGT
CCGACGATTACGACACAGACTTGCCGTTATTGATGCGGCAAGCAAGGTTACAGATATCAATATGCCTGGTTATAAGCTAC
ATCCTCTGGTGGGTGAACGCGACGGCATATGGGCAATTTCTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGATTACGAGGACTATCATTGA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT235096 WP_002364355.1 NZ_CP091895:1805396-1805728 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT235096 NZ_LR134214:c2368955-2368671 [Citrobacter portucalensis]
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCACTGGAAGAACTCAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAGATTGCACCGTCAACGGCAAGTCGACTATTAACCGGGAAAGCGGCTCTGACGCCTGAGATGGCGA
TTAAACTCTCCGTAGTGATTGGCAGTTCACCCGAAATGTGGTTAAACCTGCAAAATACCTGGAGTCTGGCAGAGGCCCAA
AAAAGCGTGGATATTTCACGTCTGCGTAAGCTGGCGGTACAGTGA
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCACTGGAAGAACTCAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAGATTGCACCGTCAACGGCAAGTCGACTATTAACCGGGAAAGCGGCTCTGACGCCTGAGATGGCGA
TTAAACTCTCCGTAGTGATTGGCAGTTCACCCGAAATGTGGTTAAACCTGCAAAATACCTGGAGTCTGGCAGAGGCCCAA
AAAAGCGTGGATATTTCACGTCTGCGTAAGCTGGCGGTACAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|