Detailed information of TA system TA023508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 3379591..3380068
• Replicon: chromosome
• Accession: NC_011901
• Organism: Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: B8GQS5
• Locus tag: TGR7_RS16205
• Protein ID: WP_012639761.1
• Coordinates: 3379591..3379857 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: B8GQS6
• Locus tag: TGR7_RS16210
• Protein ID: WP_012639762.1
• Coordinates: 3379841..3380068 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TGR7_RS16180	3376332..3376826	-	495	WP_012639756.1	Tfp pilus assembly protein PilX	-
TGR7_RS16185	3376823..3377848	-	1026	WP_012639757.1	PilW family protein	-
TGR7_RS16190	3377854..3378324	-	471	WP_095206585.1	type IV pilus modification protein PilV	-
TGR7_RS16195	3378369..3378848	-	480	WP_041442119.1	GspH/FimT family pseudopilin	-
TGR7_RS16200	3378963..3379478	-	516	WP_012639760.1	GspH/FimT family pseudopilin	-
TGR7_RS16205	3379591..3379857	-	267	WP_012639761.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TGR7_RS16210	3379841..3380068	-	228	WP_012639762.1	ribbon-helix-helix protein, CopG family	Antitoxin
TGR7_RS16220	3380350..3380790	-	441	WP_041442124.1	transcriptional repressor	-
TGR7_RS16225	3380830..3381948	-	1119	WP_012639764.1	glycine oxidase ThiO	-
TGR7_RS16235	3382203..3382403	+	201	WP_012639765.1	sulfur carrier protein ThiS	-
TGR7_RS16240	3382426..3383220	+	795	WP_012639766.1	thiazole synthase	-
TGR7_RS16245	3383397..3384089	+	693	WP_012639767.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-
TGR7_RS16250	3384150..3384992	-	843	WP_041443236.1	universal stress protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3370515..3380068	9553

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10423.13 Da
• Isoelectric Point: 10.4302

>T23508 WP_012639761.1 NC_011901:c3379857-3379591 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
VVWTIEYAQSAKKSVKGLDPPTRRRIRDYLEQRVAALQNPRGLGAPLKGEFSELWRYRIGDYRVICELQDEKLVILVIRI
AHRREVYR

Nucleotide

• Length: 267 bp

>T23508 NC_011901:c3379857-3379591 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
GTGGTCTGGACGATTGAATACGCCCAGTCCGCCAAAAAATCCGTCAAGGGACTCGATCCGCCGACAAGGCGGCGGATTCG
AGACTATCTGGAGCAGCGAGTAGCCGCTTTGCAGAACCCCAGAGGGCTTGGGGCGCCGCTCAAGGGAGAATTCTCCGAGC
TTTGGCGCTACCGCATCGGCGACTACCGGGTCATCTGCGAGTTGCAGGACGAAAAGCTCGTCATCTTGGTGATCCGCATC
GCACACAGACGAGAGGTCTATCGATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8754.65 Da
• Isoelectric Point: 4.1061

>AT23508 WP_012639762.1 NC_011901:c3380068-3379841 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MSKQTNVRLPDETYERLQALAARTGRTATYYIREAIEAQLDDLEDIYLAEQVLERIRKGEEQTLTSEEFWSGLDD

Nucleotide

• Length: 228 bp

>AT23508 NC_011901:c3380068-3379841 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGAGCAAGCAAACCAACGTCAGATTGCCCGACGAAACCTACGAGAGGCTTCAGGCACTGGCCGCACGGACCGGCCGCAC
GGCCACCTACTATATCCGCGAGGCCATCGAGGCCCAGCTGGATGACCTTGAGGACATCTATCTGGCGGAACAGGTCCTGG
AGCGTATCCGCAAGGGCGAAGAGCAGACCCTGACAAGCGAGGAGTTCTGGAGTGGTCTGGACGATTGA

Structures

Toxin

• AlphaFold DB: B8GQS5

Antitoxin

• AlphaFold DB: B8GQS6