Detailed information of TA system TA023507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 3320062..3320615
• Replicon: chromosome
• Accession: NC_011901
• Organism: Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8GQL7
• Locus tag: TGR7_RS15910
• Protein ID: WP_012639703.1
• Coordinates: 3320307..3320615 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B8GQL6
• Locus tag: TGR7_RS15905
• Protein ID: WP_012639702.1
• Coordinates: 3320062..3320319 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TGR7_RS15880	3315923..3316597	+	675	WP_012639697.1	lactate utilization protein	-
TGR7_RS15885	3316603..3316842	+	240	WP_041442089.1	hypothetical protein	-
TGR7_RS15890	3316943..3317827	+	885	WP_012639699.1	GIY-YIG nuclease family protein	-
TGR7_RS15895	3318398..3319039	+	642	WP_012639700.1	Vat family streptogramin A O-acetyltransferase	-
TGR7_RS15900	3319225..3320016	+	792	WP_012639701.1	dioxygenase	-
TGR7_RS15905	3320062..3320319	+	258	WP_012639702.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
TGR7_RS15910	3320307..3320615	+	309	WP_012639703.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TGR7_RS15915	3320630..3320989	+	360	WP_012639704.1	hypothetical protein	-
TGR7_RS15920	3321252..3323012	+	1761	WP_012639705.1	L-lactate permease	-
TGR7_RS15925	3322993..3324876	-	1884	WP_012639706.1	EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11749.54 Da
• Isoelectric Point: 5.6254

>T23507 WP_012639703.1 NC_011901:3320307-3320615 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MAEVIWTEPALSDLDAIADYIALDNPEAARTLVRKVFDHVALLADHPRLGTKPPELKGWRYRQIIEPPCRIFYRQDGDRI
FILHVMRAERLLDLSALTDPNN

Nucleotide

• Length: 309 bp

>T23507 NC_011901:3320307-3320615 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGGCTGAAGTGATCTGGACTGAACCCGCCCTCAGTGACCTGGATGCGATCGCGGACTACATCGCCCTCGACAACCCCGA
GGCGGCCAGGACTCTCGTACGCAAGGTCTTCGATCATGTCGCCTTGCTGGCTGATCACCCGAGACTGGGCACAAAGCCGC
CGGAACTGAAGGGATGGCGTTACCGCCAGATCATCGAGCCTCCTTGCCGGATCTTTTATCGACAGGACGGCGATCGCATC
TTCATACTCCACGTGATGCGCGCCGAGCGTCTGCTCGATCTATCCGCGCTCACAGATCCCAACAACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9818.38 Da
• Isoelectric Point: 10.2126

>AT23507 WP_012639702.1 NC_011901:3320062-3320319 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MRTELVTTLKRRATELLNELEQSKEPILITQHGVPSAYLVDVQSYEALQRRMHLLEGIARGEMAVEDGRTVTQAQARKRM
ARWLK

Nucleotide

• Length: 258 bp

>AT23507 NC_011901:3320062-3320319 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGCGCACCGAACTCGTCACCACCCTCAAACGCAGGGCTACCGAACTGCTCAATGAACTTGAGCAGAGCAAGGAGCCGAT
CCTCATCACGCAACATGGGGTGCCCAGCGCATACCTGGTGGATGTTCAAAGCTACGAGGCCTTACAGCGCAGGATGCACC
TGCTGGAAGGCATCGCACGGGGCGAGATGGCGGTCGAAGATGGGCGCACCGTGACCCAGGCACAGGCAAGGAAGCGCATG
GCCCGATGGCTGAAGTGA

Structures

Toxin

• AlphaFold DB: B8GQL7

Antitoxin

• AlphaFold DB: B8GQL6