Detailed information of TA system TA023506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2920066..2920546
• Replicon: chromosome
• Accession: NC_011901
• Organism: Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: TGR7_RS17290
• Protein ID: WP_012639328.1
• Coordinates: 2920066..2920332 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: TGR7_RS13945
• Protein ID: WP_041441946.1
• Coordinates: 2920316..2920546 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TGR7_RS13935	2915358..2915807	-	450	WP_012639326.1	transposase	-
TGR7_RS13940	2915957..2919826	-	3870	WP_012639327.1	DUF3683 domain-containing protein	-
TGR7_RS17290	2920066..2920332	-	267	WP_012639328.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TGR7_RS13945	2920316..2920546	-	231	WP_041441946.1	ribbon-helix-helix protein, CopG family	Antitoxin
TGR7_RS13950	2921657..2922667	-	1011	WP_012639329.1	hypothetical protein	-
TGR7_RS13955	2923165..2924229	-	1065	WP_041441949.1	porin	-
TGR7_RS13960	2924645..2924926	+	282	WP_012639331.1	hypothetical protein	-
TGR7_RS13965	2924929..2925213	+	285	WP_012639332.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-39)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10504.19 Da
• Isoelectric Point: 10.9582

>T23506 WP_012639328.1 NC_011901:c2920332-2920066 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MVWKIEFETSARKELGDLDGATARRIIRFLRDRVATSDNPRSLGKPLKGHLRDYWRYRIGDWRLVCHIDDIGVRILVIRV
SHRKDVYR

Nucleotide

• Length: 267 bp

>T23506 NC_011901:c2920332-2920066 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
TTGGTCTGGAAGATTGAGTTTGAAACATCCGCGCGCAAGGAGTTGGGTGATCTGGATGGCGCCACAGCCCGGCGGATCAT
TCGTTTCCTCCGTGATCGTGTAGCAACCTCTGACAATCCCCGTTCGCTAGGTAAACCGCTGAAGGGGCATCTTAGGGACT
ACTGGCGTTACCGCATCGGTGACTGGCGGCTGGTCTGTCACATTGACGACATAGGTGTCCGGATCCTTGTGATTCGTGTT
TCCCACCGCAAGGACGTTTACAGGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8581.61 Da
• Isoelectric Point: 4.2682

>AT23506 WP_041441946.1 NC_011901:c2920546-2920316 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MSQLAVRLPDDLSERLENLAAKTQRSKAFYVKEALRCALDDLEDIYLADARMEDLNAGRSTTHSLDEVVRDLGLED

Nucleotide

• Length: 231 bp

>AT23506 NC_011901:c2920546-2920316 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGAGCCAACTGGCCGTCAGGCTGCCAGATGACCTTAGCGAGCGGCTGGAGAACCTTGCTGCGAAGACTCAACGTAGCAA
AGCCTTCTATGTGAAGGAGGCTCTGCGGTGTGCGCTCGATGATCTTGAGGATATTTATCTGGCTGATGCGCGTATGGAAG
ATCTGAACGCTGGACGTAGCACAACCCACTCATTGGACGAGGTAGTCAGGGATCTTGGTCTGGAAGATTGA