Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 1816465..1817158 | Replicon | chromosome |
| Accession | NZ_CP091892 | ||
| Organism | Enterococcus faecalis strain 133-1 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | S4BLV4 |
| Locus tag | L5I22_RS08840 | Protein ID | WP_002378467.1 |
| Coordinates | 1816814..1817158 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | L5I22_RS08835 | Protein ID | WP_002364355.1 |
| Coordinates | 1816465..1816797 (+) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I22_RS08790 (1811937) | 1811937..1812671 | - | 735 | WP_002381724.1 | ERF family protein | - |
| L5I22_RS08795 (1812664) | 1812664..1812981 | - | 318 | WP_002401330.1 | hypothetical protein | - |
| L5I22_RS08800 (1813201) | 1813201..1813755 | + | 555 | WP_002357006.1 | hypothetical protein | - |
| L5I22_RS08805 (1814182) | 1814182..1814376 | - | 195 | WP_002381722.1 | hypothetical protein | - |
| L5I22_RS08810 (1814413) | 1814413..1814622 | - | 210 | WP_002381721.1 | hypothetical protein | - |
| L5I22_RS08815 (1814677) | 1814677..1814865 | + | 189 | WP_002357001.1 | YegP family protein | - |
| L5I22_RS08820 (1814891) | 1814891..1815616 | - | 726 | WP_002381720.1 | phage regulatory protein | - |
| L5I22_RS08825 (1815655) | 1815655..1815966 | - | 312 | WP_002381719.1 | hypothetical protein | - |
| L5I22_RS08830 (1815977) | 1815977..1816153 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| L5I22_RS08835 (1816465) | 1816465..1816797 | + | 333 | WP_002364355.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L5I22_RS08840 (1816814) | 1816814..1817158 | + | 345 | WP_002378467.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| L5I22_RS08845 (1817194) | 1817194..1817922 | + | 729 | WP_002381717.1 | potassium channel family protein | - |
| L5I22_RS08850 (1818022) | 1818022..1819170 | + | 1149 | WP_002381716.1 | site-specific integrase | - |
| L5I22_RS08855 (1819198) | 1819198..1819641 | - | 444 | WP_002381715.1 | competence type IV pilus minor pilin ComGD | - |
| L5I22_RS08860 (1819638) | 1819638..1819913 | - | 276 | WP_002356991.1 | competence type IV pilus major pilin ComGC | - |
| L5I22_RS08865 (1819913) | 1819913..1820959 | - | 1047 | WP_047649127.1 | competence type IV pilus assembly protein ComGB | - |
| L5I22_RS08870 (1820916) | 1820916..1821884 | - | 969 | WP_002401324.1 | competence type IV pilus ATPase ComGA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1770475..1838019 | 67544 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13712.62 Da Isoelectric Point: 5.5523
>T235055 WP_002378467.1 NZ_CP091892:1816814-1817158 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
Download Length: 345 bp
>T235055 NZ_LR134201:c1063317-1063102 [Cedecea lapagei]
ATGACTACCAAACTGACCAAGACCGATTATTTGATGCGTCTGCGACGTTGTCAGACAATTGATACGCTGGAACGCGTAAT
AGAAAAGAATAAATATGAATTATCAGATAATGAGCTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTCGCTGAACTGA
CAATGAATAAACTGTATGATAAAATCCCACCCTCTGTGTGGAAATTTATTCGTTAA
ATGACTACCAAACTGACCAAGACCGATTATTTGATGCGTCTGCGACGTTGTCAGACAATTGATACGCTGGAACGCGTAAT
AGAAAAGAATAAATATGAATTATCAGATAATGAGCTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTCGCTGAACTGA
CAATGAATAAACTGTATGATAAAATCCCACCCTCTGTGTGGAAATTTATTCGTTAA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT235055 WP_002364355.1 NZ_CP091892:1816465-1816797 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT235055 NZ_LR134201:c1063719-1063345 [Cedecea lapagei]
ATGGACGAGTACTCACCAAAGCGGCATGATATCGCGCAGCTGAAGTTTCTCTGTGAGAGTCTGTACCACGATTGTCTGAC
CAACCTTGGTGAGAGCAATCATGGATGGGTTAATGATCCGACTTCGGCCATAAACCTACAGCTGAATGAATTGATTGAGC
ACATTGCCGCGTCTGCGCTTAATTATAAGATTAAGTATCCGGACGAGAGCAAATTGATTGAACAGATTGATGAATACCTG
GACGATACTTTCATGTTGTTTAGCAATTACGGCATTAATGCGCAGGATCTGCAGCGGTGGCGTAAATCGGGGAATCGCTT
GTTCAGATGTTTCATTAGCGAAAGCCGAGCTAACCCAGTGAGCCATTCGTTCTAA
ATGGACGAGTACTCACCAAAGCGGCATGATATCGCGCAGCTGAAGTTTCTCTGTGAGAGTCTGTACCACGATTGTCTGAC
CAACCTTGGTGAGAGCAATCATGGATGGGTTAATGATCCGACTTCGGCCATAAACCTACAGCTGAATGAATTGATTGAGC
ACATTGCCGCGTCTGCGCTTAATTATAAGATTAAGTATCCGGACGAGAGCAAATTGATTGAACAGATTGATGAATACCTG
GACGATACTTTCATGTTGTTTAGCAATTACGGCATTAATGCGCAGGATCTGCAGCGGTGGCGTAAATCGGGGAATCGCTT
GTTCAGATGTTTCATTAGCGAAAGCCGAGCTAACCCAGTGAGCCATTCGTTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|