Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 70107..70726 | Replicon | plasmid p1 |
| Accession | NZ_CP091890 | ||
| Organism | Enterococcus faecalis strain 142-1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | R3H4V2 |
| Locus tag | L5I18_RS16285 | Protein ID | WP_000241511.1 |
| Coordinates | 70107..70469 (-) | Length | 121 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | R3H5D1 |
| Locus tag | L5I18_RS16290 | Protein ID | WP_000245205.1 |
| Coordinates | 70463..70726 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I18_RS16270 (65517) | 65517..67448 | - | 1932 | WP_002367772.1 | sucrose-specific PTS transporter subunit IIBC | - |
| L5I18_RS16275 (67639) | 67639..69078 | + | 1440 | WP_002367771.1 | sucrose-6-phosphate hydrolase | - |
| L5I18_RS16280 (69080) | 69080..70042 | + | 963 | WP_002369755.1 | LacI family DNA-binding transcriptional regulator | - |
| L5I18_RS16285 (70107) | 70107..70469 | - | 363 | WP_000241511.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| L5I18_RS16290 (70463) | 70463..70726 | - | 264 | WP_000245205.1 | PbsX family transcriptional regulator | Antitoxin |
| L5I18_RS16295 (70903) | 70903..71523 | + | 621 | WP_021732893.1 | recombinase family protein | - |
| L5I18_RS16300 (71540) | 71540..71827 | + | 288 | WP_010708491.1 | hypothetical protein | - |
| L5I18_RS16305 (71821) | 71821..72045 | + | 225 | WP_010708492.1 | ultraviolet resistance protein UvrA repressor UvrC | - |
| L5I18_RS16310 (72106) | 72106..72315 | + | 210 | WP_002387638.1 | hypothetical protein | - |
| L5I18_RS16315 (72477) | 72477..72629 | + | 153 | WP_225850000.1 | DUF6440 family protein | - |
| L5I18_RS16320 (73056) | 73056..74384 | + | 1329 | WP_021732894.1 | ultraviolet resistance protein UvrA | - |
| L5I18_RS16325 (74381) | 74381..74731 | + | 351 | WP_002399364.1 | hypothetical protein | - |
| L5I18_RS16330 (74688) | 74688..74900 | + | 213 | WP_002360669.1 | hypothetical protein | - |
| L5I18_RS16335 (74982) | 74982..75092 | + | 111 | WP_002360667.1 | type I toxin-antitoxin system Fst family toxin | - |
| - (75132) | 75132..75223 | - | 92 | NuclAT_0 | - | - |
| - (75132) | 75132..75223 | - | 92 | NuclAT_0 | - | - |
| - (75132) | 75132..75223 | - | 92 | NuclAT_0 | - | - |
| - (75132) | 75132..75223 | - | 92 | NuclAT_0 | - | - |
| L5I18_RS16340 (75332) | 75332..75628 | + | 297 | WP_002360665.1 | replication control protein PrgN | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | prgB/asc10 | 1..77272 | 77272 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13585.78 Da Isoelectric Point: 9.6107
>T235044 WP_000241511.1 NZ_CP091890:c70469-70107 [Enterococcus faecalis]
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF
Download Length: 363 bp
>T235044 NZ_LR134195:c4724985-4724710 [Raoultella ornithinolytica]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCAGCAAGCAATCTAAGAAAACATGGGATTCGGTTCGAGGAGGCGGT
ACTGGTTTTTGACGATCCGCAGCATCTTTCCCGACATGAACGCTATGAAAATGGTGAGTATCGATGGCAAACCATCGGGC
TTGTTCATGGCGTGATTGTTGTTCTTGTGGCGCATTCGATCCGATTTGAAAGTGGAACGGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAAAAATTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCAGCAAGCAATCTAAGAAAACATGGGATTCGGTTCGAGGAGGCGGT
ACTGGTTTTTGACGATCCGCAGCATCTTTCCCGACATGAACGCTATGAAAATGGTGAGTATCGATGGCAAACCATCGGGC
TTGTTCATGGCGTGATTGTTGTTCTTGTGGCGCATTCGATCCGATTTGAAAGTGGAACGGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAAAAATTATGAGCATGGTTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10059.46 Da Isoelectric Point: 5.1585
>AT235044 WP_000245205.1 NZ_CP091890:c70726-70463 [Enterococcus faecalis]
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW
Download Length: 264 bp
>AT235044 NZ_LR134195:c4724723-4724418 [Raoultella ornithinolytica]
ATGAGCATGGTTAAACATAAACGCGATAACCCGACAGCGCTTACCGCTCAGCGTGAAGACGAACTCAAAGCGCTGGCGAA
AAAATCAGATGATGACATTGATTACAGCGATATCCCCTCTTCGGACGATGGGCTGTGGTCAGATGCGGTTCGCGGTAAAT
TTTATCGGCCATTAAAAACGCAGGCCTCTGTGCGCATCGATGCAGATGTGATGGAGTGGCTTAAACGCCCGGGAAAAGGC
TATCAGACCCGGCTGAACGCGATTCTGCGGGAAGCCATGCTGCGCGAGCAGAATAAGAAATCGTAA
ATGAGCATGGTTAAACATAAACGCGATAACCCGACAGCGCTTACCGCTCAGCGTGAAGACGAACTCAAAGCGCTGGCGAA
AAAATCAGATGATGACATTGATTACAGCGATATCCCCTCTTCGGACGATGGGCTGTGGTCAGATGCGGTTCGCGGTAAAT
TTTATCGGCCATTAAAAACGCAGGCCTCTGTGCGCATCGATGCAGATGTGATGGAGTGGCTTAAACGCCCGGGAAAAGGC
TATCAGACCCGGCTGAACGCGATTCTGCGGGAAGCCATGCTGCGCGAGCAGAATAAGAAATCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|