235027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2690714..2691409 Replicon chromosome
Accession NZ_CP091889
Organism Enterococcus faecalis strain 142-1

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag L5I18_RS13660 Protein ID WP_002388462.1
Coordinates 2691065..2691409 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag L5I18_RS13655 Protein ID WP_002358111.1
Coordinates 2690714..2691046 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5I18_RS13605 (2686186) 2686186..2687001 - 816 WP_002417285.1 PD-(D/E)XK nuclease-like domain-containing protein -
L5I18_RS13610 (2686964) 2686964..2687929 - 966 WP_002415270.1 RecT family recombinase -
L5I18_RS13615 (2688030) 2688030..2688254 - 225 WP_137193403.1 hypothetical protein -
L5I18_RS13620 (2688251) 2688251..2688550 - 300 WP_137278689.1 hypothetical protein -
L5I18_RS13625 (2688617) 2688617..2688796 - 180 WP_002367283.1 hypothetical protein -
L5I18_RS13630 (2688831) 2688831..2689100 - 270 WP_002365131.1 hypothetical protein -
L5I18_RS13635 (2689176) 2689176..2689490 + 315 WP_010776102.1 hypothetical protein -
L5I18_RS16750 (2689471) 2689471..2689599 - 129 WP_010776103.1 hypothetical protein -
L5I18_RS13640 (2689747) 2689747..2689929 + 183 WP_122634212.1 hypothetical protein -
L5I18_RS13645 (2689921) 2689921..2690223 - 303 WP_104802090.1 hypothetical protein -
L5I18_RS13650 (2690236) 2690236..2690418 - 183 WP_104802091.1 hypothetical protein -
L5I18_RS13655 (2690714) 2690714..2691046 + 333 WP_002358111.1 helix-turn-helix transcriptional regulator Antitoxin
L5I18_RS13660 (2691065) 2691065..2691409 + 345 WP_002388462.1 ImmA/IrrE family metallo-endopeptidase Toxin
L5I18_RS13665 (2691498) 2691498..2692262 + 765 WP_002401991.1 LysM domain-containing protein -
L5I18_RS13670 (2692356) 2692356..2693003 - 648 WP_002365137.1 hypothetical protein -
L5I18_RS13675 (2693189) 2693189..2694370 + 1182 WP_002365138.1 site-specific integrase -
L5I18_RS13680 (2694473) 2694473..2694622 - 150 WP_002356321.1 50S ribosomal protein L33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2651235..2694370 43135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13654.62 Da        Isoelectric Point: 5.2241

>T235027 WP_002388462.1 NZ_CP091889:2691065-2691409 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMELYKIPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

>T235027 NZ_LR134193:c1560668-1560423 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12720.11 Da        Isoelectric Point: 4.5116

>AT235027 WP_002358111.1 NZ_CP091889:2690714-2691046 [Enterococcus faecalis]
MNTYEIIKDLAKEKGISIRQLEINFGYSNGYIGSWKRQTPNSNELSRLADYFDVSVDYLLGRTDNTKATDEKKFDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT235027 NZ_LR134193:1560089-1560454 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References