Detailed information of TA system TA023502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2060475..2060977
• Replicon: chromosome
• Accession: NC_011901
• Organism: Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8GT06
• Locus tag: TGR7_RS09730
• Protein ID: WP_012638500.1
• Coordinates: 2060723..2060977 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B8GT05
• Locus tag: TGR7_RS09725
• Protein ID: WP_012638499.1
• Coordinates: 2060475..2060726 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TGR7_RS09700	2056331..2056588	-	258	WP_012638494.1	cell division topological specificity factor MinE	-
TGR7_RS09705	2056592..2057401	-	810	WP_012638495.1	septum site-determining protein MinD	-
TGR7_RS09710	2057475..2058203	-	729	WP_012638496.1	septum site-determining protein MinC	-
TGR7_RS09715	2058449..2059417	+	969	WP_012638497.1	ATP-binding cassette domain-containing protein	-
TGR7_RS09720	2059621..2060382	+	762	WP_012638498.1	ABC transporter permease	-
TGR7_RS09725	2060475..2060726	+	252	WP_012638499.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
TGR7_RS09730	2060723..2060977	+	255	WP_012638500.1	Txe/YoeB family addiction module toxin	Toxin
TGR7_RS09735	2061353..2062709	+	1357	Protein_1941	saccharopine dehydrogenase NADP-binding domain-containing protein	-
TGR7_RS09740	2062846..2063256	-	411	WP_012638502.1	nuclear transport factor 2 family protein	-
TGR7_RS09745	2063412..2064371	-	960	WP_012638503.1	homocysteine S-methyltransferase family protein	-
TGR7_RS09750	2064696..2065238	-	543	WP_012638504.1	flavin reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10142.62 Da
• Isoelectric Point: 9.6404

>T23502 WP_012638500.1 NC_011901:2060723-2060977 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MKLIFSANAWEDYLYWQKTDKKTLKRINQLIAEIQRSPFEGIGKPEPLKHALLGYWSRRIDGEHRIVYRTDDDSVFIAQL
RYHY

Nucleotide

• Length: 255 bp

>T23502 NC_011901:2060723-2060977 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGAAGCTCATCTTTTCGGCGAATGCCTGGGAAGACTATCTTTACTGGCAAAAGACCGACAAGAAAACACTCAAGCGCAT
CAACCAGTTGATTGCAGAGATCCAACGATCTCCGTTTGAAGGGATCGGGAAACCCGAGCCACTGAAACATGCCCTATTGG
GCTACTGGTCACGCCGGATCGACGGTGAGCATCGCATCGTTTACCGGACTGACGATGACAGTGTGTTTATCGCGCAACTT
CGTTATCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9185.35 Da
• Isoelectric Point: 4.5994

>AT23502 WP_012638499.1 NC_011901:2060475-2060726 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MDAITYTKARANLAQTIDAVCENHEPVIVTKKNDRAVVILSLEDYQALEETAYLLRNPKNARRLLDAINELDAGGGSERT
LAE

Nucleotide

• Length: 252 bp

>AT23502 NC_011901:2060475-2060726 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGGATGCCATCACCTACACCAAGGCGCGCGCCAATCTGGCACAGACCATCGATGCCGTGTGCGAGAACCACGAACCCGT
CATTGTCACCAAGAAAAATGACCGTGCCGTCGTGATACTTTCGCTTGAGGATTACCAGGCGCTTGAGGAGACGGCATACC
TGCTTCGCAATCCCAAGAACGCCCGGCGTCTCCTCGACGCCATCAACGAGCTTGATGCGGGTGGCGGTAGCGAAAGGACG
CTGGCCGAATGA

Structures

Toxin

• AlphaFold DB: B8GT06

Antitoxin

• AlphaFold DB: B8GT05