Detailed information of TA system TA023501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1821002..1821491
• Replicon: chromosome
• Accession: NC_011901
• Organism: Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)

• Gene name: -
• Uniprot ID: B8GSA1
• Locus tag: TGR7_RS08630
• Protein ID: WP_012638287.1
• Coordinates: 1821002..1821274 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: B8GSA2
• Locus tag: TGR7_RS08635
• Protein ID: WP_012638288.1
• Coordinates: 1821255..1821491 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TGR7_RS08615	1816666..1817775	-	1110	WP_041441351.1	aminotransferase class V-fold PLP-dependent enzyme	-
TGR7_RS08620	1818081..1819448	+	1368	WP_012638285.1	lysine 2,3-aminomutase	-
TGR7_RS08625	1819614..1820969	+	1356	WP_012638286.1	adenosylmethionine--8-amino-7-oxononanoate transaminase	-
TGR7_RS08630	1821002..1821274	+	273	WP_012638287.1	BrnT family toxin	Toxin
TGR7_RS08635	1821255..1821491	+	237	WP_012638288.1	hypothetical protein	Antitoxin
TGR7_RS08640	1821542..1821835	+	294	WP_012638289.1	putative addiction module antidote protein	-
TGR7_RS08645	1821913..1824219	-	2307	WP_041441354.1	ABC transporter substrate-binding protein	-
TGR7_RS08650	1824371..1825831	-	1461	WP_012638291.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1805526..1824249	18723

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10469.03 Da
• Isoelectric Point: 9.9864

>T23501 WP_012638287.1 NC_011901:1821002-1821274 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MLSFEFDEQKSRANRAKHGIDFLDAQALWLDPALVEIPARTVDEPRFLVIGRIKGKHWSAVITHRRSRIRIISVRRARAE
EVALYESEDI

Nucleotide

• Length: 273 bp

>T23501 NC_011901:1821002-1821274 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGCTCTCATTTGAATTCGACGAGCAGAAGAGCCGGGCCAACCGTGCTAAACACGGGATCGATTTCCTTGATGCCCAGGC
GCTTTGGCTTGACCCCGCTCTCGTCGAAATCCCCGCCAGGACCGTTGATGAGCCACGGTTTCTGGTCATTGGCAGGATCA
AGGGGAAGCACTGGTCGGCAGTCATCACGCACAGGCGCAGCCGTATCCGAATCATCTCTGTTCGTCGGGCCCGGGCCGAA
GAGGTAGCCCTTTATGAAAGCGAAGACATTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9114.38 Da
• Isoelectric Point: 10.3815

>AT23501 WP_012638288.1 NC_011901:1821255-1821491 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MKAKTFDSKFDNGEDVTDHLDVAKARRPLQKQRRVNVDFPDWMIESLDREASRLGVTRQSIIKVWLAERLEQTAAKRT

Nucleotide

• Length: 237 bp

>AT23501 NC_011901:1821255-1821491 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGAAAGCGAAGACATTTGATAGCAAATTTGACAACGGCGAGGACGTCACAGACCACCTGGACGTTGCAAAGGCCCGCCG
CCCACTGCAGAAGCAGCGAAGAGTCAATGTGGACTTCCCGGACTGGATGATCGAATCCCTGGACCGGGAGGCCAGTCGCC
TGGGCGTCACGCGTCAATCGATCATCAAGGTCTGGTTGGCCGAACGCCTGGAGCAGACCGCCGCCAAGCGGACGTGA

Structures

Toxin

• AlphaFold DB: B8GSA1

Antitoxin

• AlphaFold DB: B8GSA2