Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 1512619..1513756 | Replicon | chromosome |
| Accession | NZ_CP091886 | ||
| Organism | Enterococcus faecalis strain 143-1 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | L5I19_RS07365 | Protein ID | WP_002401483.1 |
| Coordinates | 1512619..1513482 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | R2XCR7 |
| Locus tag | L5I19_RS07370 | Protein ID | WP_000301765.1 |
| Coordinates | 1513484..1513756 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I19_RS07340 (1508068) | 1508068..1508919 | - | 852 | WP_002357480.1 | ribosome biogenesis GTPase YlqF | - |
| L5I19_RS07345 (1509114) | 1509114..1509794 | - | 681 | WP_010710189.1 | IS6-like element IS1216 family transposase | - |
| L5I19_RS07350 (1509868) | 1509868..1510155 | - | 288 | Protein_1420 | DnaJ domain-containing protein | - |
| L5I19_RS07355 (1510333) | 1510333..1511652 | + | 1320 | WP_002338419.1 | IS1380-like element ISSsu5 family transposase | - |
| L5I19_RS07360 (1511861) | 1511861..1512178 | - | 318 | WP_002333463.1 | hypothetical protein | - |
| L5I19_RS07365 (1512619) | 1512619..1513482 | - | 864 | WP_002401483.1 | zeta toxin family protein | Toxin |
| L5I19_RS07370 (1513484) | 1513484..1513756 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
| L5I19_RS07375 (1513773) | 1513773..1513988 | - | 216 | WP_002401482.1 | peptide-binding protein | - |
| L5I19_RS07380 (1514087) | 1514087..1514983 | - | 897 | WP_002387620.1 | ParA family protein | - |
| L5I19_RS07385 (1515086) | 1515086..1515346 | - | 261 | Protein_1427 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| L5I19_RS07390 (1515516) | 1515516..1516253 | - | 738 | WP_002292226.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| L5I19_RS07395 (1516378) | 1516378..1516473 | - | 96 | WP_001809736.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| L5I19_RS07400 (1516542) | 1516542..1516664 | - | 123 | Protein_1430 | peptide-binding protein | - |
| L5I19_RS07405 (1516784) | 1516784..1518310 | - | 1527 | WP_025191980.1 | type IA DNA topoisomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | erm(B) / aph(3')-III / ant(6)-Ia / aac(6')-aph(2'') | - | 1509114..1526965 | 17851 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32486.06 Da Isoelectric Point: 6.9965
>T235007 WP_002401483.1 NZ_CP091886:c1513482-1512619 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
Download Length: 864 bp
>T235007 NZ_LR134171:c13307-12999 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACACGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACACGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT235007 WP_000301765.1 NZ_CP091886:c1513756-1513484 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT235007 NZ_LR134171:c13603-13307 [Haemophilus influenzae]
ATGGCAATTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA
ATGGCAATTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|