Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 1814610..1815722 | Replicon | chromosome |
| Accession | NC_011901 | ||
| Organism | Thioalkalivibrio sulfidophilus HL-EbGr7 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | B8GS94 |
| Locus tag | TGR7_RS08600 | Protein ID | WP_012638280.1 |
| Coordinates | 1814610..1815356 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | B8GS95 |
| Locus tag | TGR7_RS08605 | Protein ID | WP_012638281.1 |
| Coordinates | 1815357..1815722 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TGR7_RS08575 | 1810136..1810582 | - | 447 | WP_012638276.1 | DUF302 domain-containing protein | - |
| TGR7_RS08580 | 1810924..1811574 | + | 651 | WP_081434269.1 | sigma-70 family RNA polymerase sigma factor | - |
| TGR7_RS08585 | 1811571..1811807 | + | 237 | WP_012638278.1 | zf-HC2 domain-containing protein | - |
| TGR7_RS08590 | 1811888..1812841 | + | 954 | WP_012637613.1 | IS5 family transposase | - |
| TGR7_RS08595 | 1813019..1814254 | + | 1236 | WP_012638279.1 | methyltransferase domain-containing protein | - |
| TGR7_RS08600 | 1814610..1815356 | - | 747 | WP_012638280.1 | RES family NAD+ phosphorylase | Toxin |
| TGR7_RS08605 | 1815357..1815722 | - | 366 | WP_012638281.1 | MbcA/ParS/Xre antitoxin family protein | Antitoxin |
| TGR7_RS08610 | 1815775..1816455 | + | 681 | WP_012638282.1 | metallophosphoesterase | - |
| TGR7_RS08615 | 1816666..1817775 | - | 1110 | WP_041441351.1 | aminotransferase class V-fold PLP-dependent enzyme | - |
| TGR7_RS08620 | 1818081..1819448 | + | 1368 | WP_012638285.1 | lysine 2,3-aminomutase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1805526..1824249 | 18723 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 27895.79 Da Isoelectric Point: 7.1179
>T23500 WP_012638280.1 NC_011901:c1815356-1814610 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
VYPDIWAACRETAAPGPLKGTLLRLVESQEQVATNRLVDSLEEQAALEAMLEATKPPLPAEGPRHYLLVTPFRYPPLRHG
SRFGRRFEPSLFYGSLSLSTLLAEAAFYRFYFWYGMAIPPASALVTRHTVFEAAYRSRRGLRLQEPPFDAFRDALTHPAD
YRATQQLGTALREAGVQAFEYRSARDEGINVALFTPRALADARPRSQEHWLCETDGAHVRFLGETQTQVHVLPLERFLVE
GVLPMPAA
VYPDIWAACRETAAPGPLKGTLLRLVESQEQVATNRLVDSLEEQAALEAMLEATKPPLPAEGPRHYLLVTPFRYPPLRHG
SRFGRRFEPSLFYGSLSLSTLLAEAAFYRFYFWYGMAIPPASALVTRHTVFEAAYRSRRGLRLQEPPFDAFRDALTHPAD
YRATQQLGTALREAGVQAFEYRSARDEGINVALFTPRALADARPRSQEHWLCETDGAHVRFLGETQTQVHVLPLERFLVE
GVLPMPAA
Download Length: 747 bp
>T23500 NC_011901:c1815356-1814610 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
GTGTATCCTGATATCTGGGCCGCCTGTCGGGAGACCGCCGCGCCGGGCCCGCTCAAGGGCACCCTGCTGCGCCTGGTGGA
AAGCCAGGAACAGGTGGCCACCAACCGGCTGGTGGACTCCCTGGAGGAGCAGGCCGCTCTCGAGGCCATGCTGGAGGCCA
CCAAGCCCCCCCTGCCCGCCGAAGGACCGCGCCACTACCTGCTCGTCACCCCGTTCCGCTACCCGCCCCTGCGCCACGGC
TCCCGGTTCGGCCGCCGCTTCGAGCCGAGCCTCTTCTACGGCTCGCTGAGCCTGTCCACCCTGCTGGCCGAAGCCGCCTT
CTACCGATTCTATTTCTGGTACGGCATGGCGATCCCGCCCGCCAGCGCCCTGGTGACCCGGCACACGGTGTTCGAGGCCG
CCTACCGCAGCCGCCGGGGACTGCGACTCCAGGAACCGCCCTTTGACGCCTTTCGGGACGCGCTCACCCACCCCGCCGAC
TATCGCGCCACCCAGCAGCTGGGCACGGCCCTGCGCGAGGCGGGGGTGCAGGCCTTCGAGTACCGCTCGGCGCGGGATGA
GGGCATCAACGTCGCCCTGTTCACGCCCCGGGCTCTGGCCGATGCCCGGCCCCGGTCACAGGAACACTGGCTGTGCGAAA
CGGACGGCGCACACGTGCGCTTCCTGGGCGAGACCCAGACCCAGGTGCATGTGTTGCCGTTGGAAAGGTTTCTGGTGGAG
GGGGTGTTGCCGATGCCGGCGGCATGA
GTGTATCCTGATATCTGGGCCGCCTGTCGGGAGACCGCCGCGCCGGGCCCGCTCAAGGGCACCCTGCTGCGCCTGGTGGA
AAGCCAGGAACAGGTGGCCACCAACCGGCTGGTGGACTCCCTGGAGGAGCAGGCCGCTCTCGAGGCCATGCTGGAGGCCA
CCAAGCCCCCCCTGCCCGCCGAAGGACCGCGCCACTACCTGCTCGTCACCCCGTTCCGCTACCCGCCCCTGCGCCACGGC
TCCCGGTTCGGCCGCCGCTTCGAGCCGAGCCTCTTCTACGGCTCGCTGAGCCTGTCCACCCTGCTGGCCGAAGCCGCCTT
CTACCGATTCTATTTCTGGTACGGCATGGCGATCCCGCCCGCCAGCGCCCTGGTGACCCGGCACACGGTGTTCGAGGCCG
CCTACCGCAGCCGCCGGGGACTGCGACTCCAGGAACCGCCCTTTGACGCCTTTCGGGACGCGCTCACCCACCCCGCCGAC
TATCGCGCCACCCAGCAGCTGGGCACGGCCCTGCGCGAGGCGGGGGTGCAGGCCTTCGAGTACCGCTCGGCGCGGGATGA
GGGCATCAACGTCGCCCTGTTCACGCCCCGGGCTCTGGCCGATGCCCGGCCCCGGTCACAGGAACACTGGCTGTGCGAAA
CGGACGGCGCACACGTGCGCTTCCTGGGCGAGACCCAGACCCAGGTGCATGTGTTGCCGTTGGAAAGGTTTCTGGTGGAG
GGGGTGTTGCCGATGCCGGCGGCATGA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13071.06 Da Isoelectric Point: 9.7591
>AT23500 WP_012638281.1 NC_011901:c1815722-1815357 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MSQLATATPRTDPAQVLTKAFLNAGKELGLNRAALGQVIGKDRSTLTRGQIDPDSKAGELALLLVRCYRALFVLVGGDPE
QLRHWMHTANHHTGGVPAEQVLTAQGLVRVTEYLDAMRGKV
MSQLATATPRTDPAQVLTKAFLNAGKELGLNRAALGQVIGKDRSTLTRGQIDPDSKAGELALLLVRCYRALFVLVGGDPE
QLRHWMHTANHHTGGVPAEQVLTAQGLVRVTEYLDAMRGKV
Download Length: 366 bp
>AT23500 NC_011901:c1815722-1815357 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGAGCCAGCTTGCCACCGCCACTCCTCGTACTGATCCCGCCCAGGTGCTCACCAAGGCGTTTCTCAATGCTGGCAAGGA
ACTGGGACTCAACCGCGCCGCCCTGGGCCAGGTGATCGGCAAGGACCGCAGCACCCTCACCCGGGGCCAGATCGATCCCG
ACAGCAAGGCCGGGGAACTGGCGCTGCTGCTGGTGCGCTGCTACCGGGCCCTGTTCGTGCTGGTGGGCGGCGATCCCGAA
CAGCTGCGCCACTGGATGCACACGGCCAACCACCACACCGGCGGCGTCCCGGCCGAGCAGGTGCTCACGGCCCAGGGTCT
GGTCAGAGTGACAGAATACCTCGACGCGATGCGAGGCAAAGTCTGA
ATGAGCCAGCTTGCCACCGCCACTCCTCGTACTGATCCCGCCCAGGTGCTCACCAAGGCGTTTCTCAATGCTGGCAAGGA
ACTGGGACTCAACCGCGCCGCCCTGGGCCAGGTGATCGGCAAGGACCGCAGCACCCTCACCCGGGGCCAGATCGATCCCG
ACAGCAAGGCCGGGGAACTGGCGCTGCTGCTGGTGCGCTGCTACCGGGCCCTGTTCGTGCTGGTGGGCGGCGATCCCGAA
CAGCTGCGCCACTGGATGCACACGGCCAACCACCACACCGGCGGCGTCCCGGCCGAGCAGGTGCTCACGGCCCAGGGTCT
GGTCAGAGTGACAGAATACCTCGACGCGATGCGAGGCAAAGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|