Detailed information of TA system TA234991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907(toxin)
• Location: 2847770..2848341
• Replicon: chromosome
• Accession: NZ_CP091884
• Organism: Enterococcus faecalis strain 152

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: L5I24_RS13925
• Protein ID: WP_002354774.1
• Coordinates: 2847770..2848111 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: R3JGB1
• Locus tag: L5I24_RS13930
• Protein ID: WP_002354773.1
• Coordinates: 2848111..2848341 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I24_RS13920 (2843785)	2843785..2847399	-	3615	WP_010774058.1	DNA-directed RNA polymerase subunit beta	-
L5I24_RS13925 (2847770)	2847770..2848111	-	342	WP_002354774.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
L5I24_RS13930 (2848111)	2848111..2848341	-	231	WP_002354773.1	hypothetical protein	Antitoxin
L5I24_RS13935 (2848515)	2848515..2848730	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
L5I24_RS13940 (2848869)	2848869..2849861	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
L5I24_RS13945 (2850028)	2850028..2850666	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
L5I24_RS13950 (2851351)	2851351..2852967	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13156.40 Da
• Isoelectric Point: 9.3984

>T234991 WP_002354774.1 NZ_CP091884:c2848111-2847770 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Nucleotide

• Length: 342 bp

>T234991 NZ_LR134167:1869712-1869960 [Avibacterium volantium]
ATGGGAAAATCTGAAAAATTATTAGAAAAATTAGCTAATGCTAAAAATACCTTTATTTGGACAGATTTACTCACCTTATT
AGCTCGGTTAGGCTATGAAAAACGTGAAATGGCTGGCTCTCGCGTTAGATTTTACAACGCAGAGCTTGATCACTTAATCT
TGTTACATAAACCGCACCCTGAAAATTACATCAAAGGTGGGGCGTTAAAATCAGTGAAAGATGGATTAAAAGGAGTGGGA
TTACTATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8677.67 Da
• Isoelectric Point: 4.3313

>AT234991 WP_002354773.1 NZ_CP091884:c2848341-2848111 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Nucleotide

• Length: 231 bp

>AT234991 NZ_LR134167:1869957-1870298 [Avibacterium volantium]
ATGACATTACTCAAATACAAAGGTTATGTTGGCACCATAGAAGCAGATTTAGAAAATAATGTGCTATTTGGCAAATTGGC
ATATATCCGAGATGTGGTTACCTACGAAGCGGAAACCTTGCCACAATTAGAGAAAGAATTTCAAACTTCTGTGGATCTGT
ATTTGCAAGATTGCCAAGAGCTTGGGCGAACGCCTGACAAACCTTTCAAAGGCGTATTTAATGTGAGAATTAGCGAAGAA
CTTCACCGTAATGCCGTGTTAGCGGCGGGTGATCTTAGCTTGAATGCCTTTGTTGCCGAAGCAATTAAAGAAAAAGTAGA
GCGTGCTGGCATTACAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0M2A812