Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-DinJ |
| Location | 424655..425189 | Replicon | chromosome |
| Accession | NZ_CP091884 | ||
| Organism | Enterococcus faecalis strain 152 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | R3JX52 |
| Locus tag | L5I24_RS02195 | Protein ID | WP_002360769.1 |
| Coordinates | 424914..425189 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | R3H6P0 |
| Locus tag | L5I24_RS02190 | Protein ID | WP_002369771.1 |
| Coordinates | 424655..424921 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I24_RS02155 (420705) | 420705..421298 | + | 594 | WP_002414802.1 | replication-relaxation family protein | - |
| L5I24_RS02160 (421304) | 421304..421792 | + | 489 | WP_010710133.1 | hypothetical protein | - |
| L5I24_RS02165 (422384) | 422384..422650 | + | 267 | WP_002377947.1 | hypothetical protein | - |
| L5I24_RS02170 (422683) | 422683..423183 | + | 501 | WP_002360775.1 | DnaJ domain-containing protein | - |
| L5I24_RS02175 (423196) | 423196..423444 | + | 249 | WP_002360773.1 | DUF3850 domain-containing protein | - |
| L5I24_RS02180 (423520) | 423520..423936 | + | 417 | WP_010710134.1 | single-stranded DNA-binding protein | - |
| L5I24_RS02185 (423960) | 423960..424544 | + | 585 | WP_002377949.1 | thermonuclease family protein | - |
| L5I24_RS02190 (424655) | 424655..424921 | + | 267 | WP_002369771.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| L5I24_RS02195 (424914) | 424914..425189 | + | 276 | WP_002360769.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| L5I24_RS02200 (425380) | 425380..426024 | - | 645 | WP_002377952.1 | IS6 family transposase | - |
| L5I24_RS02205 (426248) | 426248..427222 | + | 975 | WP_002355428.1 | choloylglycine hydrolase | - |
| L5I24_RS02210 (427891) | 427891..428499 | - | 609 | Protein_412 | IS6 family transposase | - |
| L5I24_RS02215 (428531) | 428531..428716 | - | 186 | WP_002358660.1 | hypothetical protein | - |
| L5I24_RS02220 (428746) | 428746..429075 | + | 330 | WP_002358661.1 | LPXTG cell wall anchor domain-containing protein | - |
| L5I24_RS02225 (429203) | 429203..430141 | + | 939 | WP_002370935.1 | 2-dehydropantoate 2-reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | EF0485 / bsh / cylR2 / cylR1 / cylL / cylS / cylM / cylB / cylA / cylI / esp / psaA | 396803..520302 | 123499 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10732.58 Da Isoelectric Point: 9.6918
>T234982 WP_002360769.1 NZ_CP091884:424914-425189 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
Download Length: 276 bp
>T234982 NZ_LR134164:3402199-3402519 [Enterobacter hormaechei]
ATGAAAACTCTACCCGCAACGACTTTGTGGGCGGCTAAACCATGCCCGTCACCAGTGATCGTATGGCAAATGCTTCTTTC
ACGCCTGCTGGATCAGCACTATGGCCTGACACTGAATGACACGCCATTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGCCGATGCCGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATCGATCGTAAGGGATTT
AGCTGGCAAGAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAACTTA
A
ATGAAAACTCTACCCGCAACGACTTTGTGGGCGGCTAAACCATGCCCGTCACCAGTGATCGTATGGCAAATGCTTCTTTC
ACGCCTGCTGGATCAGCACTATGGCCTGACACTGAATGACACGCCATTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGCCGATGCCGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATCGATCGTAAGGGATTT
AGCTGGCAAGAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAACTTA
A
Antitoxin
Download Length: 89 a.a. Molecular weight: 9772.09 Da Isoelectric Point: 4.4791
>AT234982 WP_002369771.1 NZ_CP091884:424655-424921 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
Download Length: 267 bp
>AT234982 NZ_LR134164:3401861-3402178 [Enterobacter hormaechei]
ATGAGCAACATTACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGATCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGTAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGCCATGCCCACTGCGTCACCCTGTGCCAC
AATGGTTTCACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCACCGTTTATCCCACTCACCGATAA
ATGAGCAACATTACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGATCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGTAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGCCATGCCCACTGCGTCACCCTGTGCCAC
AATGGTTTCACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCACCGTTTATCCCACTCACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2AEA7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2AED7 |