Detailed information of TA system TA023498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 1417011..1417669
• Replicon: chromosome
• Accession: NC_011901
• Organism: Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TGR7_RS06605
• Protein ID: WP_012637887.1
• Coordinates: 1417247..1417669 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B8GQY3
• Locus tag: TGR7_RS06600
• Protein ID: WP_012637886.1
• Coordinates: 1417011..1417250 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TGR7_RS06585	1412553..1412813	+	261	WP_049764627.1	glycosyltransferase	-
TGR7_RS06590	1412934..1414907	+	1974	WP_012637882.1	capsular polysaccharide biosynthesis protein	-
TGR7_RS17060	1415378..1415614	+	237	WP_012637883.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
TGR7_RS17065	1415614..1416042	+	429	WP_012637884.1	type II toxin-antitoxin system VapC family toxin	-
TGR7_RS17070	1416278..1416817	+	540	WP_012637885.1	transposase	-
TGR7_RS06600	1417011..1417250	+	240	WP_012637886.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TGR7_RS06605	1417247..1417669	+	423	WP_012637887.1	type II toxin-antitoxin system VapC family toxin	Toxin
TGR7_RS06615	1418245..1420338	-	2094	WP_049764720.1	STAS domain-containing protein	-
TGR7_RS06620	1420856..1421728	-	873	WP_012637889.1	flagellar motor protein MotB	-
TGR7_RS06625	1421735..1422592	-	858	WP_012637890.1	flagellar motor stator protein MotA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-126)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14727.92 Da
• Isoelectric Point: 4.8499

>T23498 WP_012637887.1 NC_011901:1417247-1417669 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MSSPRYLLDTNVISELVRHPQGVVAKQIAAVGETAVCTSIVVAAELRFGAAKRDSLHLTNQVDAILGAMDVLPLDAPADS
AYAQLRAALEKSGRPIGPNDMLIAAHALAAECVLVTANTDEFSRVPGLRVENWLAGLVGE

Nucleotide

• Length: 423 bp

>T23498 NC_011901:1417247-1417669 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGAGTTCGCCGCGTTATTTGCTGGACACAAATGTTATTTCGGAGCTGGTTCGCCATCCGCAGGGCGTTGTGGCCAAGCA
GATTGCCGCAGTTGGCGAAACGGCGGTGTGTACATCGATCGTGGTAGCCGCCGAATTGCGGTTTGGGGCGGCGAAGCGGG
ATTCGTTACACCTGACAAATCAGGTGGATGCAATCCTGGGGGCGATGGATGTGTTGCCGCTTGATGCGCCAGCCGATAGC
GCATATGCACAATTGCGAGCGGCGCTTGAGAAATCCGGTCGGCCGATTGGTCCCAACGATATGTTGATCGCCGCACATGC
CCTGGCTGCGGAGTGTGTTCTGGTTACGGCTAATACGGATGAGTTTTCCCGGGTACCGGGTTTACGGGTGGAAAATTGGC
TTGCCGGTTTGGTTGGTGAATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9167.50 Da
• Isoelectric Point: 4.6558

>AT23498 WP_012637886.1 NC_011901:1417011-1417250 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MSTERHVRLFRNGRNQAIRIPREFEFDVQEAIIRREDDRLIIEPVRRVSLLAVLATLSPIEEKFPDVDAGLPALDDIDL

Nucleotide

• Length: 240 bp

>AT23498 NC_011901:1417011-1417250 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGTCTACAGAGCGTCATGTCAGGTTGTTTCGTAATGGACGTAATCAGGCCATTCGGATCCCCCGGGAATTTGAATTCGA
TGTGCAGGAGGCGATTATCCGACGCGAGGATGATCGCTTGATTATCGAGCCCGTACGGAGAGTGAGTTTGTTGGCCGTGT
TGGCAACCTTGTCGCCAATCGAGGAAAAATTTCCGGATGTCGATGCGGGGTTGCCGGCGTTGGATGACATTGATCTATGA

Structures

Antitoxin

• AlphaFold DB: B8GQY3