Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 121034..122053 | Replicon | chromosome |
| Accession | NZ_CP091884 | ||
| Organism | Enterococcus faecalis strain 152 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | Q839N5 |
| Locus tag | L5I24_RS00520 | Protein ID | WP_002359283.1 |
| Coordinates | 121034..121672 (-) | Length | 213 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | L5I24_RS00525 | Protein ID | WP_002359284.1 |
| Coordinates | 121679..122053 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I24_RS00495 (116951) | 116951..118219 | + | 1269 | WP_002356139.1 | RidA family protein | - |
| L5I24_RS00500 (118269) | 118269..118712 | - | 444 | WP_002356140.1 | MepB family protein | - |
| L5I24_RS00505 (118727) | 118727..119272 | - | 546 | WP_002401626.1 | ATP:cob(I)alamin adenosyltransferase | - |
| L5I24_RS00510 (119423) | 119423..119719 | - | 297 | WP_002391749.1 | hypothetical protein | - |
| L5I24_RS00515 (120417) | 120417..120992 | + | 576 | WP_002359282.1 | restriction endonuclease | - |
| L5I24_RS00520 (121034) | 121034..121672 | - | 639 | WP_002359283.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| L5I24_RS00525 (121679) | 121679..122053 | - | 375 | WP_002359284.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L5I24_RS00530 (122895) | 122895..123077 | - | 183 | WP_002359286.1 | hypothetical protein | - |
| L5I24_RS00535 (123244) | 123244..123495 | + | 252 | WP_002359287.1 | hypothetical protein | - |
| L5I24_RS00540 (123582) | 123582..123908 | + | 327 | WP_002359288.1 | hypothetical protein | - |
| L5I24_RS00545 (123908) | 123908..124315 | + | 408 | WP_002359289.1 | DUF961 family protein | - |
| L5I24_RS00550 (124465) | 124465..124689 | + | 225 | WP_002359290.1 | hypothetical protein | - |
| L5I24_RS00555 (124718) | 124718..124909 | + | 192 | WP_010773668.1 | hypothetical protein | - |
| L5I24_RS00560 (124891) | 124891..125295 | + | 405 | WP_002359292.1 | hypothetical protein | - |
| L5I24_RS00565 (125407) | 125407..125739 | + | 333 | WP_002359293.1 | nucleotidyltransferase domain-containing protein | - |
| L5I24_RS00570 (125729) | 125729..126112 | + | 384 | WP_002359294.1 | DUF86 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | EF0149 / tufA | 114566..191804 | 77238 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 213 a.a. Molecular weight: 25186.21 Da Isoelectric Point: 9.1676
>T234979 WP_002359283.1 NZ_CP091884:c121672-121034 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDMPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILLK
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDMPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILLK
Download Length: 639 bp
>T234979 NZ_LR134164:c1099734-1099516 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACTATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACTATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14518.29 Da Isoelectric Point: 4.8896
>AT234979 WP_002359284.1 NZ_CP091884:c122053-121679 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE
Download Length: 375 bp
>AT234979 NZ_LR134164:c1100137-1099763 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|