Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 989708..990492 | Replicon | chromosome |
| Accession | NC_011901 | ||
| Organism | Thioalkalivibrio sulfidophilus HL-EbGr7 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | B8GNR8 |
| Locus tag | TGR7_RS04555 | Protein ID | WP_012637492.1 |
| Coordinates | 989995..990492 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | B8GNR7 |
| Locus tag | TGR7_RS04550 | Protein ID | WP_012637491.1 |
| Coordinates | 989708..989998 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TGR7_RS04525 | 984835..985698 | - | 864 | WP_012637487.1 | phosphate/phosphite/phosphonate ABC transporter substrate-binding protein | - |
| TGR7_RS04530 | 985695..986522 | - | 828 | WP_012637488.1 | phosphonate ABC transporter ATP-binding protein | - |
| TGR7_RS04535 | 986865..987843 | + | 979 | Protein_913 | IS5 family transposase | - |
| TGR7_RS04540 | 987969..988778 | + | 810 | WP_012637489.1 | hypothetical protein | - |
| TGR7_RS04545 | 988894..989559 | + | 666 | WP_012637490.1 | transposase | - |
| TGR7_RS04550 | 989708..989998 | + | 291 | WP_012637491.1 | DUF1778 domain-containing protein | Antitoxin |
| TGR7_RS04555 | 989995..990492 | + | 498 | WP_012637492.1 | GNAT family N-acetyltransferase | Toxin |
| TGR7_RS04560 | 990651..991175 | + | 525 | WP_012637493.1 | HIT family protein | - |
| TGR7_RS04565 | 991309..991578 | + | 270 | WP_012637494.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TGR7_RS04570 | 991991..992296 | + | 306 | WP_041440957.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TGR7_RS04575 | 992513..992929 | + | 417 | WP_012637496.1 | 30S ribosomal protein S6 | - |
| TGR7_RS04580 | 992964..993188 | + | 225 | WP_012637497.1 | 30S ribosomal protein S18 | - |
| TGR7_RS04585 | 993235..994131 | + | 897 | WP_012637498.1 | DUF2232 domain-containing protein | - |
| TGR7_RS04590 | 994193..994645 | + | 453 | WP_012637499.1 | 50S ribosomal protein L9 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 980425..992296 | 11871 | |
| - | flank | IS/Tn | - | - | 987235..987843 | 608 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18288.04 Da Isoelectric Point: 9.6505
>T23497 WP_012637492.1 NC_011901:989995-990492 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MSLSGPEPLGPQHRIEGFDCGKPTLNDWLVRHARQAQGSGSAKTFVVSEDDRVAGYFSLTVGQVDALDAPERIRKGMGQY
PIPVVILARLAVSRQDQGRGIGIGLLQDAIRRTLLIAEQAGIRAMLTHPIDEQAARFYTRFGFIASPLREQQLLLLLKDA
RRWVE
MSLSGPEPLGPQHRIEGFDCGKPTLNDWLVRHARQAQGSGSAKTFVVSEDDRVAGYFSLTVGQVDALDAPERIRKGMGQY
PIPVVILARLAVSRQDQGRGIGIGLLQDAIRRTLLIAEQAGIRAMLTHPIDEQAARFYTRFGFIASPLREQQLLLLLKDA
RRWVE
Download Length: 498 bp
>T23497 NC_011901:989995-990492 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGAGCTTGAGTGGCCCGGAACCCCTTGGGCCACAGCATCGGATCGAAGGTTTTGATTGCGGCAAACCGACGCTCAATGA
CTGGCTGGTGCGCCATGCCCGACAGGCGCAAGGCAGCGGCTCCGCCAAGACCTTCGTCGTCAGCGAAGACGATCGGGTCG
CCGGTTATTTCAGCCTGACCGTCGGCCAGGTCGACGCGCTCGATGCGCCAGAGCGCATTCGCAAGGGCATGGGACAGTAT
CCGATCCCCGTCGTGATCCTTGCCCGTCTGGCCGTCAGTCGGCAGGATCAGGGCCGAGGGATCGGCATCGGTCTGTTACA
GGATGCCATCCGCCGCACCCTGCTGATTGCCGAGCAGGCCGGCATCCGGGCGATGCTGACCCACCCCATCGATGAGCAAG
CAGCGAGGTTCTATACCCGCTTCGGCTTCATTGCCTCACCGCTGCGCGAGCAGCAACTCTTGCTGCTGCTCAAGGATGCC
CGCCGCTGGGTCGAGTGA
ATGAGCTTGAGTGGCCCGGAACCCCTTGGGCCACAGCATCGGATCGAAGGTTTTGATTGCGGCAAACCGACGCTCAATGA
CTGGCTGGTGCGCCATGCCCGACAGGCGCAAGGCAGCGGCTCCGCCAAGACCTTCGTCGTCAGCGAAGACGATCGGGTCG
CCGGTTATTTCAGCCTGACCGTCGGCCAGGTCGACGCGCTCGATGCGCCAGAGCGCATTCGCAAGGGCATGGGACAGTAT
CCGATCCCCGTCGTGATCCTTGCCCGTCTGGCCGTCAGTCGGCAGGATCAGGGCCGAGGGATCGGCATCGGTCTGTTACA
GGATGCCATCCGCCGCACCCTGCTGATTGCCGAGCAGGCCGGCATCCGGGCGATGCTGACCCACCCCATCGATGAGCAAG
CAGCGAGGTTCTATACCCGCTTCGGCTTCATTGCCTCACCGCTGCGCGAGCAGCAACTCTTGCTGCTGCTCAAGGATGCC
CGCCGCTGGGTCGAGTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10665.09 Da Isoelectric Point: 5.8270
>AT23497 WP_012637491.1 NC_011901:989708-989998 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MATTTPSATRSARLGLRATLEQEAVLRRAADVAHKSLTDFILDSACQAAEQTLLDQRLFMVSGSQYQALMDLLERPEQAN
EGLRDLFSRKAPWDKA
MATTTPSATRSARLGLRATLEQEAVLRRAADVAHKSLTDFILDSACQAAEQTLLDQRLFMVSGSQYQALMDLLERPEQAN
EGLRDLFSRKAPWDKA
Download Length: 291 bp
>AT23497 NC_011901:989708-989998 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGGCTACCACTACCCCTTCAGCGACACGTTCCGCCCGCCTGGGATTGCGTGCCACGCTCGAGCAGGAAGCCGTCCTGCG
CCGCGCCGCCGACGTGGCGCACAAGTCGTTGACGGATTTCATTCTCGACAGCGCCTGCCAGGCCGCCGAGCAAACCCTGC
TCGACCAACGCTTGTTCATGGTCTCGGGAAGCCAGTATCAGGCCCTGATGGATCTGCTGGAACGTCCCGAACAGGCCAAC
GAGGGGCTGCGCGATCTGTTCTCGCGGAAGGCCCCTTGGGACAAGGCATGA
ATGGCTACCACTACCCCTTCAGCGACACGTTCCGCCCGCCTGGGATTGCGTGCCACGCTCGAGCAGGAAGCCGTCCTGCG
CCGCGCCGCCGACGTGGCGCACAAGTCGTTGACGGATTTCATTCTCGACAGCGCCTGCCAGGCCGCCGAGCAAACCCTGC
TCGACCAACGCTTGTTCATGGTCTCGGGAAGCCAGTATCAGGCCCTGATGGATCTGCTGGAACGTCCCGAACAGGCCAAC
GAGGGGCTGCGCGATCTGTTCTCGCGGAAGGCCCCTTGGGACAAGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|