Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4313210..4313991 Replicon chromosome
Accession NZ_CP091878
Organism Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag L8I56_RS20960 Protein ID WP_000625911.1
Coordinates 4313210..4313701 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag L8I56_RS20965 Protein ID WP_001271379.1
Coordinates 4313698..4313991 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8I56_RS20935 (4310090) 4310090..4310920 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
L8I56_RS20940 (4311122) 4311122..4311334 - 213 WP_001293880.1 PapB/FocB family fimbrial expression transcriptional regulator -
L8I56_RS20945 (4311960) 4311960..4312103 + 144 Protein_4108 transposase -
L8I56_RS20950 (4312120) 4312120..4312466 + 347 Protein_4109 Rpn family recombination-promoting nuclease/putative transposase -
L8I56_RS20955 (4312747) 4312747..4312995 - 249 Protein_4110 IS481 family transposase -
L8I56_RS20960 (4313210) 4313210..4313701 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
L8I56_RS20965 (4313698) 4313698..4313991 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
L8I56_RS20970 (4314309) 4314309..4314530 + 222 WP_001595143.1 hypothetical protein -
L8I56_RS20975 (4314796) 4314796..4315671 + 876 WP_238124111.1 AraC family transcriptional regulator -
L8I56_RS20980 (4315668) 4315668..4315955 + 288 WP_001541332.1 transcriptional regulator RtsB -
L8I56_RS20985 (4315948) 4315948..4316130 - 183 WP_023252989.1 ATP-binding cassette domain-containing protein -
L8I56_RS20990 (4316150) 4316150..4316249 + 100 Protein_4117 hypothetical protein -
L8I56_RS20995 (4316357) 4316357..4316491 + 135 Protein_4118 hypothetical protein -
L8I56_RS21000 (4316786) 4316786..4317691 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4301704..4316130 14426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T234969 WP_000625911.1 NZ_CP091878:c4313701-4313210 [Salmonella enterica subsp. enterica serovar Tennessee]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T234969 NZ_LR134161:c2858403-2858309 [Yersinia enterocolitica subsp. enterocolitica]
AACAAGCCTACGTTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATCGT
ATTCGGTCTTTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT234969 WP_001271379.1 NZ_CP091878:c4313991-4313698 [Salmonella enterica subsp. enterica serovar Tennessee]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT234969 NZ_LR134161:2858307-2858425 [Yersinia enterocolitica subsp. enterocolitica]
ATAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAACGTAGGCTTGTTCAGCCATACTCTTTAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References