Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4175823..4176339 Replicon chromosome
Accession NZ_CP091878
Organism Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L8I56_RS20240 Protein ID WP_000220578.1
Coordinates 4175823..4176107 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L8I56_RS20245 Protein ID WP_000212724.1
Coordinates 4176097..4176339 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8I56_RS20225 (4171035) 4171035..4172687 + 1653 WP_000155043.1 alpha,alpha-phosphotrehalase -
L8I56_RS20230 (4173096) 4173096..4175234 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
L8I56_RS20235 (4175355) 4175355..4175819 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L8I56_RS20240 (4175823) 4175823..4176107 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8I56_RS20245 (4176097) 4176097..4176339 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L8I56_RS20250 (4176417) 4176417..4178330 - 1914 WP_001212156.1 BglG family transcription antiterminator -
L8I56_RS20255 (4178347) 4178347..4179087 - 741 WP_000779248.1 KDGP aldolase family protein -
L8I56_RS20260 (4179084) 4179084..4180202 - 1119 WP_001139179.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L8I56_RS20265 (4180186) 4180186..4181319 - 1134 WP_238124109.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T234968 WP_000220578.1 NZ_CP091878:c4176107-4175823 [Salmonella enterica subsp. enterica serovar Tennessee]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T234968 NZ_LR134161:2228524-2228802 [Yersinia enterocolitica subsp. enterocolitica]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
AAATAAACTTAAAACTATTATGGCGCTGCTAATTGACGATAAATTACCCTTGCCTGTTATATACAAGGATCATCAATTAC
AAGGTAATTACAAAGGTTACAGGGATGCGCATATAGAGCCAGACTGGCTTATCATCTACAAGATTACTGATGATTTGCTT
CGCTTCGAAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT234968 WP_000212724.1 NZ_CP091878:c4176339-4176097 [Salmonella enterica subsp. enterica serovar Tennessee]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT234968 NZ_LR134161:2228257-2228517 [Yersinia enterocolitica subsp. enterocolitica]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGATGAAACCCTAAAAAATGAAGCCGCTGCTGTGCTTGCTGGCATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTCGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACCGCTAAAACTATTGCCAACAGCGAGAAAGGTGTCGATGTCCACAAAGCAAAGGATGCCGATGATCTG
TTTGATAAATTAGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References