Detailed information of TA system TA234967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 4133928..4134478
• Replicon: chromosome
• Accession: NZ_CP091878
• Organism: Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: M7RJ32
• Locus tag: L8I56_RS20020
• Protein ID: WP_001199743.1
• Coordinates: 4133928..4134236 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A3W0H141
• Locus tag: L8I56_RS20025
• Protein ID: WP_000016242.1
• Coordinates: 4134239..4134478 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8I56_RS20000 (4129286)	4129286..4130413	-	1128	WP_001288808.1	DGQHR domain-containing protein DpdB	-
L8I56_RS20005 (4130410)	4130410..4131660	-	1251	WP_001542917.1	tRNA-guanine transglycosylase DpdA	-
L8I56_RS20010 (4131734)	4131734..4132690	-	957	WP_223196638.1	DUF5069 domain-containing protein	-
L8I56_RS20015 (4133451)	4133451..4133549	-	99	Protein_3926	hypothetical protein	-
L8I56_RS20020 (4133928)	4133928..4134236	-	309	WP_001199743.1	CcdB family protein	Toxin
L8I56_RS20025 (4134239)	4134239..4134478	-	240	WP_000016242.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
L8I56_RS20030 (4134587)	4134587..4134835	-	249	WP_000168385.1	ribbon-helix-helix domain-containing protein	-
L8I56_RS20035 (4134912)	4134912..4135220	-	309	Protein_3930	DUF4942 domain-containing protein	-
L8I56_RS20040 (4135240)	4135240..4136217	-	978	WP_223196639.1	IS630 family transposase	-
L8I56_RS20055 (4136975)	4136975..4137994	+	1020	WP_000152568.1	NAD(P)-dependent alcohol dehydrogenase	-
L8I56_RS20060 (4138022)	4138022..4138552	-	531	WP_000896756.1	gluconokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4135240..4136172	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (9-79)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11845.67 Da
• Isoelectric Point: 6.7228

>T234967 WP_001199743.1 NZ_CP091878:c4134236-4133928 [Salmonella enterica subsp. enterica serovar Tennessee]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Nucleotide

• Length: 309 bp

>T234967 NZ_LR134161:1219641-1219937 [Yersinia enterocolitica subsp. enterocolitica]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8767.89 Da
• Isoelectric Point: 5.6726

>AT234967 WP_000016242.1 NZ_CP091878:c4134478-4134239 [Salmonella enterica subsp. enterica serovar Tennessee]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATDVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Nucleotide

• Length: 240 bp

>AT234967 NZ_LR134161:1219937-1220335 [Yersinia enterocolitica subsp. enterocolitica]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTACTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTAG

Structures

Toxin

• AlphaFold DB: A0A6C6Z9V9

Antitoxin

• AlphaFold DB: A0A3W0H141