Detailed information of TA system TA234963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3469772..3470392
• Replicon: chromosome
• Accession: NZ_CP091878
• Organism: Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: L8I56_RS17010
• Protein ID: WP_001280991.1
• Coordinates: 3470174..3470392 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: L8I56_RS17005
• Protein ID: WP_000344807.1
• Coordinates: 3469772..3470146 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8I56_RS16995 (3464911)	3464911..3466104	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
L8I56_RS17000 (3466127)	3466127..3469276	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
L8I56_RS17005 (3469772)	3469772..3470146	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
L8I56_RS17010 (3470174)	3470174..3470392	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
L8I56_RS17015 (3470571)	3470571..3471122	+	552	WP_001278790.1	maltose O-acetyltransferase	-
L8I56_RS17020 (3471240)	3471240..3471710	+	471	WP_000136183.1	YlaC family protein	-
L8I56_RS17025 (3471766)	3471766..3471906	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
L8I56_RS17030 (3471912)	3471912..3472172	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
L8I56_RS17035 (3472397)	3472397..3473947	+	1551	WP_000213143.1	EAL domain-containing protein	-
L8I56_RS17045 (3474177)	3474177..3474566	+	390	WP_000961285.1	MGMT family protein	-
L8I56_RS17050 (3474599)	3474599..3475168	-	570	WP_000779801.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T234963 WP_001280991.1 NZ_CP091878:3470174-3470392 [Salmonella enterica subsp. enterica serovar Tennessee]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T234963 NZ_LR134161:708411-708665 [Yersinia enterocolitica subsp. enterocolitica]
GTGAGAATTATATTTTCCAGTTGTTCTTGGGAGGATTATCTTTATTGGCAACAAACGGATAAGAAAATCCTCAAACGCAT
TAATGAGTTAGTAAAAAATATTCAAAGAACGCCATTTGAGGGAAAGGGTAAACCGGAACCCCTTAAACATAATCTGGCAG
GGTTCTGGTCACGGAGGATTACAGAAGAGCACAGACTTGTTTATGAGGTTTCCGGTGATAATTTATTAATTGCTGCTTGT
CGTTACCATTATTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT234963 WP_000344807.1 NZ_CP091878:3469772-3470146 [Salmonella enterica subsp. enterica serovar Tennessee]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT234963 NZ_LR134161:708163-708414 [Yersinia enterocolitica subsp. enterocolitica]
ATGAGAACAATTAGTTATAGTGAGGCGCGCCAGAATTTGTCGACAACGATGGTGCAAACGGTTGAGGATCGAGCCCCCAT
CCTCATCACTCGTCAAAATGGGACTTCTTGTGTTCTTATGTCACTTGAAGAATATGAATCATTGGAAGAAACTGCTTATT
TACTGCGCTCACCAGCAAACGCGAAGCATTTGATGGACTCAATTGAAGAGTTGAGAGCAGGAAAAGGAATTCAAAGGGAA
CTTGAAGAGTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0