Detailed information of TA system TA234962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2474704..2475226
• Replicon: chromosome
• Accession: NZ_CP091878
• Organism: Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: V7IL40
• Locus tag: L8I56_RS12115
• Protein ID: WP_000221345.1
• Coordinates: 2474942..2475226 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: L8I56_RS12110
• Protein ID: WP_000885424.1
• Coordinates: 2474704..2474952 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8I56_RS12075 (2469750)	2469750..2470730	-	981	WP_000876809.1	nitronate monooxygenase	-
L8I56_RS12080 (2470904)	2470904..2471812	-	909	WP_001176635.1	LysR family transcriptional regulator	-
L8I56_RS12085 (2472214)	2472214..2472402	+	189	WP_001276025.1	DUF29 family protein	-
L8I56_RS12090 (2472679)	2472679..2472996	-	318	WP_000253165.1	DUF1493 family protein	-
L8I56_RS12095 (2473065)	2473065..2473181	-	117	Protein_2371	IS110 family transposase	-
L8I56_RS12100 (2473546)	2473546..2473935	+	390	WP_001044696.1	hypothetical protein	-
L8I56_RS12105 (2473938)	2473938..2474291	+	354	WP_000418733.1	hypothetical protein	-
L8I56_RS12110 (2474704)	2474704..2474952	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L8I56_RS12115 (2474942)	2474942..2475226	+	285	WP_000221345.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L8I56_RS12120 (2475397)	2475397..2475738	+	342	WP_001537886.1	RidA family protein	-
L8I56_RS12125 (2475838)	2475838..2476917	-	1080	WP_023199483.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
L8I56_RS12130 (2477110)	2477110..2477598	-	489	WP_001293634.1	MarR family winged helix-turn-helix transcriptional regulator	-
L8I56_RS12135 (2477643)	2477643..2479151	+	1509	WP_000199413.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2468032..2482008	13976

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11043.79 Da
• Isoelectric Point: 10.6500

>T234962 WP_000221345.1 NZ_CP091878:2474942-2475226 [Salmonella enterica subsp. enterica serovar Tennessee]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Nucleotide

• Length: 285 bp

>T234962 NZ_LR134161:708163-708414 [Yersinia enterocolitica subsp. enterocolitica]
ATGAGAACAATTAGTTATAGTGAGGCGCGCCAGAATTTGTCGACAACGATGGTGCAAACGGTTGAGGATCGAGCCCCCAT
CCTCATCACTCGTCAAAATGGGACTTCTTGTGTTCTTATGTCACTTGAAGAATATGAATCATTGGAAGAAACTGCTTATT
TACTGCGCTCACCAGCAAACGCGAAGCATTTGATGGACTCAATTGAAGAGTTGAGAGCAGGAAAAGGAATTCAAAGGGAA
CTTGAAGAGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT234962 WP_000885424.1 NZ_CP091878:2474704-2474952 [Salmonella enterica subsp. enterica serovar Tennessee]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT234962 NZ_LR134161:708411-708665 [Yersinia enterocolitica subsp. enterocolitica]
GTGAGAATTATATTTTCCAGTTGTTCTTGGGAGGATTATCTTTATTGGCAACAAACGGATAAGAAAATCCTCAAACGCAT
TAATGAGTTAGTAAAAAATATTCAAAGAACGCCATTTGAGGGAAAGGGTAAACCGGAACCCCTTAAACATAATCTGGCAG
GGTTCTGGTCACGGAGGATTACAGAAGAGCACAGACTTGTTTATGAGGTTTCCGGTGATAATTTATTAATTGCTGCTTGT
CGTTACCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A5Y2FFA8

Antitoxin

• AlphaFold DB: A0A5I0WPN5