Detailed information of TA system TA023496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 644933..645495
• Replicon: chromosome
• Accession: NC_011901
• Organism: Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B8GLV3
• Locus tag: TGR7_RS03025
• Protein ID: WP_012637194.1
• Coordinates: 644933..645301 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B8GLV4
• Locus tag: TGR7_RS03030
• Protein ID: WP_012637195.1
• Coordinates: 645298..645495 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TGR7_RS03010	640195..642204	-	2010	WP_012637191.1	site-specific recombinase	-
TGR7_RS03015	642313..644097	-	1785	WP_012637192.1	C4-dicarboxylic acid transporter DauA	-
TGR7_RS03020	644255..644734	-	480	WP_012637193.1	LEA type 2 family protein	-
TGR7_RS03025	644933..645301	-	369	WP_012637194.1	type II toxin-antitoxin system VapC family toxin	Toxin
TGR7_RS03030	645298..645495	-	198	WP_012637195.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TGR7_RS03035	645911..647074	-	1164	Protein_608	type II toxin-antitoxin system HipA family toxin	-
TGR7_RS17415	647349..647492	-	144	Protein_609	HipA N-terminal domain-containing protein	-
TGR7_RS03045	647489..647869	-	381	WP_148211456.1	helix-turn-helix domain-containing protein	-
TGR7_RS03050	648048..648728	+	681	Protein_611	hypothetical protein	-
TGR7_RS03055	648795..650042	-	1248	WP_012637198.1	serine hydroxymethyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	635222..657262	22040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13469.53 Da
• Isoelectric Point: 5.1406

>T23496 WP_012637194.1 NC_011901:c645301-644933 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MILVDTSVWVDHLRTGDAVLAELLNRSQVLMHPFVVGELACGNLRNRSEVLRLLKDLPQAVVASDEEVLFFIERNALKGL
GIGYVDAHLLAAVTLGGSTQLWTRDKRLRSVAETLNLAYGED

Nucleotide

• Length: 369 bp

>T23496 NC_011901:c645301-644933 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGATCCTGGTTGATACCTCGGTCTGGGTCGATCACCTGCGCACCGGTGATGCGGTGCTCGCGGAGTTGCTGAACCGCAG
TCAGGTGCTGATGCACCCTTTCGTGGTCGGTGAGCTGGCCTGCGGCAACCTGCGTAACCGCAGCGAGGTACTGCGGCTGC
TCAAGGACCTACCGCAAGCGGTCGTTGCCAGCGATGAGGAGGTGCTGTTTTTCATCGAACGCAACGCGCTGAAGGGCCTG
GGCATCGGTTACGTGGATGCGCACCTGCTGGCCGCGGTGACCTTGGGCGGCTCGACGCAACTGTGGACACGGGACAAGCG
TCTGCGGTCGGTGGCCGAGACCCTGAACCTCGCCTATGGCGAGGATTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7257.28 Da
• Isoelectric Point: 9.1096

>AT23496 WP_012637195.1 NC_011901:c645495-645298 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MRTTLNIDDQLLAEAQRITGMTEKAALVREGLRALIERESARRLARLGGSEPQLETVPRRQSDPA

Nucleotide

• Length: 198 bp

>AT23496 NC_011901:c645495-645298 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGCGTACAACCCTGAACATCGATGACCAGTTACTGGCCGAAGCCCAACGCATCACCGGAATGACCGAAAAAGCCGCCCT
GGTGCGGGAGGGGCTGCGCGCCTTGATCGAGCGCGAGAGCGCCCGGCGGCTGGCACGGCTGGGCGGCAGTGAACCGCAGT
TGGAGACCGTGCCCCGCCGACAGTCCGATCCGGCATGA

Structures

Toxin

• AlphaFold DB: B8GLV3

Antitoxin

• AlphaFold DB: B8GLV4