Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1064572..1065386 | Replicon | chromosome |
| Accession | NZ_CP091878 | ||
| Organism | Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3G3DUX8 |
| Locus tag | L8I56_RS05130 | Protein ID | WP_000971653.1 |
| Coordinates | 1064572..1065099 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | L8I56_RS05135 | Protein ID | WP_000855694.1 |
| Coordinates | 1065096..1065386 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L8I56_RS05100 (1060845) | 1060845..1061243 | + | 399 | Protein_1004 | cytoplasmic protein | - |
| L8I56_RS05105 (1061434) | 1061434..1061673 | + | 240 | Protein_1005 | hypothetical protein | - |
| L8I56_RS05110 (1061830) | 1061830..1062498 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| L8I56_RS05115 (1062525) | 1062525..1063019 | + | 495 | WP_000424942.1 | hypothetical protein | - |
| L8I56_RS05120 (1063191) | 1063191..1063847 | - | 657 | WP_000420464.1 | protein-serine/threonine phosphatase | - |
| L8I56_RS05125 (1064081) | 1064081..1064499 | + | 419 | Protein_1009 | transposase | - |
| L8I56_RS05130 (1064572) | 1064572..1065099 | - | 528 | WP_000971653.1 | GNAT family N-acetyltransferase | Toxin |
| L8I56_RS05135 (1065096) | 1065096..1065386 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| L8I56_RS05140 (1065656) | 1065656..1065856 | - | 201 | Protein_1012 | IS3 family transposase | - |
| L8I56_RS05145 (1066097) | 1066097..1066423 | + | 327 | WP_000393297.1 | hypothetical protein | - |
| L8I56_RS05150 (1066695) | 1066695..1067042 | - | 348 | WP_001555786.1 | DUF1493 family protein | - |
| L8I56_RS05155 (1067027) | 1067027..1067476 | - | 450 | WP_000381616.1 | hypothetical protein | - |
| L8I56_RS05160 (1067895) | 1067895..1068338 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| L8I56_RS05165 (1068795) | 1068795..1069445 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1064359..1074758 | 10399 | |
| - | flank | IS/Tn | - | - | 1064359..1064499 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19043.87 Da Isoelectric Point: 9.7032
>T234953 WP_000971653.1 NZ_CP091878:c1065099-1064572 [Salmonella enterica subsp. enterica serovar Tennessee]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T234953 NZ_LR134152:3680092-3680370 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT234953 WP_000855694.1 NZ_CP091878:c1065386-1065096 [Salmonella enterica subsp. enterica serovar Tennessee]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT234953 NZ_LR134152:3679829-3680089 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3DUX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |