Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878791..879451 Replicon chromosome
Accession NZ_CP091878
Organism Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L8I56_RS04275 Protein ID WP_000244756.1
Coordinates 879038..879451 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L8I56_RS04270 Protein ID WP_000351186.1
Coordinates 878791..879057 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8I56_RS04250 (874720) 874720..876153 - 1434 WP_001230144.1 6-phospho-beta-glucosidase BglA -
L8I56_RS04255 (876311) 876311..876622 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L8I56_RS04260 (876786) 876786..877445 + 660 WP_000250289.1 hemolysin III family protein -
L8I56_RS04265 (877561) 877561..878541 - 981 WP_000874164.1 tRNA-modifying protein YgfZ -
L8I56_RS04270 (878791) 878791..879057 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L8I56_RS04275 (879038) 879038..879451 + 414 WP_000244756.1 protein YgfX Toxin
L8I56_RS04280 (879504) 879504..880025 - 522 WP_001055885.1 flavodoxin FldB -
L8I56_RS04285 (880138) 880138..881034 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L8I56_RS04290 (881058) 881058..881771 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L8I56_RS04295 (881777) 881777..883510 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T234952 WP_000244756.1 NZ_CP091878:879038-879451 [Salmonella enterica subsp. enterica serovar Tennessee]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T234952 NZ_LR134152:c3674029-3673679 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT234952 WP_000351186.1 NZ_CP091878:878791-879057 [Salmonella enterica subsp. enterica serovar Tennessee]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234952 NZ_LR134152:c3674325-3674032 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5


Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References