Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 336112..336698 | Replicon | chromosome |
| Accession | NZ_CP091878 | ||
| Organism | Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A0R9MYB2 |
| Locus tag | L8I56_RS01525 | Protein ID | WP_000174966.1 |
| Coordinates | 336330..336698 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A0R9PI96 |
| Locus tag | L8I56_RS01520 | Protein ID | WP_001535398.1 |
| Coordinates | 336112..336333 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L8I56_RS01495 (331132) | 331132..332241 | + | 1110 | WP_000822983.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
| L8I56_RS01500 (332301) | 332301..333227 | + | 927 | WP_000003005.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| L8I56_RS01505 (333224) | 333224..334501 | + | 1278 | WP_000803766.1 | branched chain amino acid ABC transporter permease LivM | - |
| L8I56_RS01510 (334498) | 334498..335265 | + | 768 | WP_000082083.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| L8I56_RS01515 (335267) | 335267..335980 | + | 714 | WP_000416114.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| L8I56_RS01520 (336112) | 336112..336333 | + | 222 | WP_001535398.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| L8I56_RS01525 (336330) | 336330..336698 | + | 369 | WP_000174966.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| L8I56_RS01530 (336957) | 336957..338273 | + | 1317 | WP_000624751.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| L8I56_RS01535 (338378) | 338378..339265 | + | 888 | WP_000099303.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| L8I56_RS01540 (339262) | 339262..340107 | + | 846 | WP_000572196.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| L8I56_RS01545 (340109) | 340109..341179 | + | 1071 | WP_000907838.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 331132..341916 | 10784 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13629.91 Da Isoelectric Point: 6.4657
>T234951 WP_000174966.1 NZ_CP091878:336330-336698 [Salmonella enterica subsp. enterica serovar Tennessee]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLTISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLTISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
Download Length: 369 bp
>T234951 NZ_LR134152:c3624646-3624278 [Escherichia coli]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCTTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGGGATCAAACCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGTCGTTAACTTTCTTGTAGAAAAGCATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACTGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCACGGCAGTGA
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCTTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGGGATCAAACCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGTCGTTAACTTTCTTGTAGAAAAGCATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACTGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCACGGCAGTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8165.23 Da Isoelectric Point: 6.4643
>AT234951 WP_001535398.1 NZ_CP091878:336112-336333 [Salmonella enterica subsp. enterica serovar Tennessee]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK
Download Length: 222 bp
>AT234951 NZ_LR134152:c3624984-3624667 [Escherichia coli]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACTCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAACGCTAA
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACTCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R9MYB2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R9PI96 |