234950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 226072..226832 Replicon chromosome
Accession NZ_CP091878
Organism Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L8I56_RS01040 Protein ID WP_000533909.1
Coordinates 226347..226832 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag L8I56_RS01035 Protein ID WP_000965889.1
Coordinates 226072..226359 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8I56_RS01020 (221405) 221405..222772 - 1368 WP_000874091.1 DUF4147 domain-containing protein -
L8I56_RS01025 (222832) 222832..224148 - 1317 WP_000098993.1 MFS transporter -
L8I56_RS01030 (224281) 224281..225573 - 1293 WP_000097706.1 phosphopyruvate hydratase -
L8I56_RS01035 (226072) 226072..226359 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
L8I56_RS01040 (226347) 226347..226832 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L8I56_RS01045 (227204) 227204..227743 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
L8I56_RS01050 (227916) 227916..228128 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L8I56_RS01055 (228416) 228416..228706 - 291 WP_000455790.1 HTH-type transcriptional regulator -
L8I56_RS01060 (229145) 229145..229855 + 711 WP_000190524.1 DUF3053 domain-containing protein -
L8I56_RS01065 (229905) 229905..230879 - 975 WP_000804672.1 glyoxylate/hydroxypyruvate reductase GhrB -
L8I56_RS01070 (231109) 231109..231771 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 216963..226832 9869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T234950 WP_000533909.1 NZ_CP091878:226347-226832 [Salmonella enterica subsp. enterica serovar Tennessee]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T234950 NZ_LR134152:3438735-3438953 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT234950 WP_000965889.1 NZ_CP091878:226072-226359 [Salmonella enterica subsp. enterica serovar Tennessee]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT234950 NZ_LR134152:3438335-3438709 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References