Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 348787..349423 Replicon chromosome
Accession NC_011901
Organism Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag TGR7_RS16940 Protein ID WP_041440735.1
Coordinates 348787..349095 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag TGR7_RS16945 Protein ID WP_081434236.1
Coordinates 349088..349423 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TGR7_RS01505 345910..346800 - 891 WP_012636893.1 LysR family transcriptional regulator -
TGR7_RS01510 346898..348586 + 1689 WP_012636894.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
TGR7_RS16940 348787..349095 + 309 WP_041440735.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TGR7_RS16945 349088..349423 + 336 WP_081434236.1 putative addiction module antidote protein Antitoxin
TGR7_RS01520 349555..349878 - 324 WP_012636895.1 hypothetical protein -
TGR7_RS01525 350081..350419 - 339 WP_012636896.1 hypothetical protein -
TGR7_RS01530 350854..352563 + 1710 WP_012636897.1 HAMP domain-containing histidine kinase -
TGR7_RS16950 352622..353599 - 978 WP_012636898.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11630.22 Da        Isoelectric Point: 9.3652

>T23495 WP_041440735.1 NC_011901:348787-349095 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MYTFLRTPEFDSWLKKLRDPIGKARIIARIRSAEAGNFGDCEPVGKGVSEMRIHYGPGYRVYHARDGETIYLLLCGGNKS
TQKKDIQKAHDLAEKYRGHTDD

Download         Length: 309 bp

>T23495 NC_011901:348787-349095 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGTACACATTCCTTCGTACGCCAGAGTTTGATAGCTGGCTGAAGAAGCTTCGAGATCCGATAGGAAAAGCTCGAATCAT
CGCCCGTATCCGTTCTGCCGAGGCAGGAAACTTCGGCGACTGCGAACCTGTCGGGAAGGGTGTCTCGGAGATGAGAATCC
ATTACGGACCTGGTTACAGGGTGTATCACGCAAGGGACGGCGAAACGATTTACCTTCTTCTGTGTGGAGGCAATAAATCA
ACTCAGAAGAAGGACATCCAGAAAGCCCATGACCTTGCTGAGAAATACCGAGGCCACACTGATGACTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12220.99 Da        Isoelectric Point: 8.4661

>AT23495 WP_081434236.1 NC_011901:349088-349423 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MTKLTKFDAAEYLDSEEVIAEYLNAALEDEDPNVFLVAIGDIAKARGMTELAREAGLGRESLYKALTPGAKPRYDTVLRV
IRALGVELHTVPVHQKPVPTRRSSGRASARR

Download         Length: 336 bp

>AT23495 NC_011901:349088-349423 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGACTAAGTTGACCAAATTCGATGCCGCAGAATACCTGGATAGCGAAGAGGTAATTGCAGAATACCTCAATGCTGCGCT
AGAGGACGAAGATCCAAATGTATTTCTGGTGGCTATTGGCGATATCGCAAAGGCACGAGGGATGACGGAGCTGGCCAGAG
AAGCTGGACTTGGTCGAGAGAGCCTGTATAAGGCCTTAACTCCCGGTGCAAAGCCACGATATGACACCGTTTTGAGAGTA
ATACGAGCACTAGGCGTAGAGCTGCATACCGTGCCAGTGCATCAGAAACCAGTTCCAACCAGGCGTTCCAGCGGACGCGC
TAGCGCACGCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References