234949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1962175..1962652 Replicon chromosome
Accession NZ_CP091876
Organism Staphylococcus aureus strain FRI-1169

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag MAK06_RS09940 Protein ID WP_000052078.1
Coordinates 1962464..1962652 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MAK06_RS09935 Protein ID WP_001059690.1
Coordinates 1962175..1962435 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK06_RS09900 (1957568) 1957568..1958284 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
MAK06_RS09905 (1958432) 1958432..1958854 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
MAK06_RS09910 (1959253) 1959253..1959747 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
MAK06_RS09915 (1959902) 1959902..1960519 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
MAK06_RS09920 (1960592) 1960592..1961173 - 582 WP_001140686.1 histidine phosphatase family protein -
MAK06_RS09925 (1961398) 1961398..1961634 + 237 WP_000368687.1 hypothetical protein -
MAK06_RS09930 (1961631) 1961631..1961834 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MAK06_RS09935 (1962175) 1962175..1962435 + 261 WP_001059690.1 hypothetical protein Antitoxin
MAK06_RS09940 (1962464) 1962464..1962652 + 189 WP_000052078.1 hypothetical protein Toxin
MAK06_RS09945 (1962840) 1962840..1963409 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
MAK06_RS09950 (1963497) 1963497..1963781 + 285 WP_001004395.1 hypothetical protein -
MAK06_RS09955 (1963843) 1963843..1964061 + 219 WP_000005886.1 hypothetical protein -
MAK06_RS09960 (1964557) 1964557..1964757 - 201 WP_001059082.1 cold-shock protein -
MAK06_RS09965 (1965114) 1965114..1965800 - 687 WP_001548082.1 thermonuclease family protein -
MAK06_RS09970 (1966141) 1966141..1966611 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tsst-1 / selq / selk / vWbp 1935605..1969845 34240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T234949 WP_000052078.1 NZ_CP091876:1962464-1962652 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T234949 NZ_LR134152:2646734-2646841 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT234949 WP_001059690.1 NZ_CP091876:1962175-1962435 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT234949 NZ_LR134152:c2646687-2646621 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References