Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1945004..1945536 Replicon chromosome
Accession NZ_CP091876
Organism Staphylococcus aureus strain FRI-1169

Toxin (Protein)


Gene name TscT Uniprot ID Q8VLW9
Locus tag MAK06_RS09805 Protein ID WP_001103944.1
Coordinates 1945004..1945324 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MAK06_RS09810 Protein ID WP_001058486.1
Coordinates 1945327..1945536 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK06_RS09775 (1940215) 1940215..1940556 - 342 WP_001190615.1 hypothetical protein -
MAK06_RS09780 (1941006) 1941006..1941647 - 642 WP_001019780.1 hypothetical protein -
MAK06_RS09785 (1941644) 1941644..1941928 - 285 WP_000998182.1 hypothetical protein -
MAK06_RS09790 (1941930) 1941930..1942292 - 363 WP_001039174.1 hypothetical protein -
MAK06_RS09795 (1942594) 1942594..1944051 - 1458 WP_000432708.1 virulence-associated E family protein -
MAK06_RS09800 (1944068) 1944068..1944937 - 870 WP_001002693.1 primase alpha helix C-terminal domain-containing protein -
MAK06_RS09805 (1945004) 1945004..1945324 - 321 WP_001103944.1 DUF1474 family protein Toxin
MAK06_RS09810 (1945327) 1945327..1945536 - 210 WP_001058486.1 hypothetical protein Antitoxin
MAK06_RS09815 (1945529) 1945529..1945675 - 147 WP_000784893.1 hypothetical protein -
MAK06_RS09820 (1945687) 1945687..1945959 - 273 WP_001138298.1 helix-turn-helix domain-containing protein -
MAK06_RS09825 (1945960) 1945960..1946172 - 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
MAK06_RS09830 (1946322) 1946322..1947056 + 735 WP_000142630.1 helix-turn-helix transcriptional regulator -
MAK06_RS09835 (1947231) 1947231..1947959 + 729 WP_001033317.1 staphylococcal enterotoxin type Q -
MAK06_RS09840 (1947983) 1947983..1948711 + 729 WP_000733773.1 staphylococcal enterotoxin type K -
MAK06_RS09845 (1948799) 1948799..1950019 + 1221 WP_000264181.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tsst-1 / selq / selk / vWbp 1935605..1969845 34240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12636.31 Da        Isoelectric Point: 4.8519

>T234948 WP_001103944.1 NZ_CP091876:c1945324-1945004 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Download         Length: 321 bp

>T234948 NZ_LR134152:2646199-2646306 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT234948 WP_001058486.1 NZ_CP091876:c1945536-1945327 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT234948 NZ_LR134152:c2646152-2646086 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8VLW9

Antitoxin

Source ID Structure

References