Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 680832..681346 Replicon chromosome
Accession NZ_CP091876
Organism Staphylococcus aureus strain FRI-1169

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MAK06_RS03445 Protein ID WP_000581792.1
Coordinates 681137..681346 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MAK06_RS03440 Protein ID WP_000138932.1
Coordinates 680832..681125 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK06_RS03420 (676095) 676095..676736 + 642 WP_000483153.1 thiamine phosphate synthase -
MAK06_RS03425 (676822) 676822..677694 + 873 WP_000725802.1 membrane protein insertase YidC -
MAK06_RS03430 (678507) 678507..679154 - 648 WP_001187629.1 HD domain-containing protein -
MAK06_RS03435 (679182) 679182..680666 - 1485 WP_000571549.1 cardiolipin synthase -
MAK06_RS03440 (680832) 680832..681125 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MAK06_RS03445 (681137) 681137..681346 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MAK06_RS03450 (681474) 681474..681611 + 138 WP_000828354.1 Lmo0850 family protein -
MAK06_RS03455 (681875) 681875..683077 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MAK06_RS03460 (683395) 683395..684465 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MAK06_RS03465 (684480) 684480..685838 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T234940 WP_000581792.1 NZ_CP091876:681137-681346 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T234940 NZ_LR134152:647312-647626 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT234940 WP_000138932.1 NZ_CP091876:680832-681125 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT234940 NZ_LR134152:647623-648039 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References