Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2303785..2304299 Replicon chromosome
Accession NZ_CP091875
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MAK07_RS11570 Protein ID WP_000581791.1
Coordinates 2303785..2303994 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MAK07_RS11575 Protein ID WP_000138934.1
Coordinates 2304006..2304299 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK07_RS11550 (2299674) 2299674..2300744 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
MAK07_RS11555 (2301062) 2301062..2302264 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MAK07_RS11560 (2302425) 2302425..2303108 - 684 Protein_2243 transposase -
MAK07_RS11565 (2303520) 2303520..2303657 - 138 WP_000828354.1 Lmo0850 family protein -
MAK07_RS11570 (2303785) 2303785..2303994 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MAK07_RS11575 (2304006) 2304006..2304299 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MAK07_RS11580 (2304465) 2304465..2305949 + 1485 WP_000571560.1 cardiolipin synthase -
MAK07_RS11585 (2305977) 2305977..2306624 + 648 WP_001187612.1 HD domain-containing protein -
MAK07_RS11590 (2306781) 2306781..2307080 + 300 WP_001793952.1 hypothetical protein -
MAK07_RS11595 (2307237) 2307237..2308109 - 873 WP_000725802.1 membrane protein insertase YidC -
MAK07_RS11600 (2308195) 2308195..2308836 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T234926 WP_000581791.1 NZ_CP091875:c2303994-2303785 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T234926 NZ_LR134151:c1116107-1115904 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGACGACGAGCTCGAGCTGTTTTACTCCGCAGCAGACCACCGTCTTGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCTGTTGCCGTTTGGAAATTCGTAAGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT234926 WP_000138934.1 NZ_CP091875:c2304299-2304006 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT234926 NZ_LR134151:c1116526-1116158 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTACGATGAAGGTATCGC
CACTCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCAGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTACGGTATTAACGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References