Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 2097735..2098523 | Replicon | chromosome |
| Accession | NZ_CP091875 | ||
| Organism | Staphylococcus aureus strain MN8 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MAK07_RS10380 | Protein ID | WP_000525004.1 |
| Coordinates | 2098062..2098523 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | MAK07_RS10375 | Protein ID | WP_000333630.1 |
| Coordinates | 2097735..2098049 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAK07_RS10320 (2093142) | 2093142..2093765 | - | 624 | WP_000139720.1 | DUF1071 domain-containing protein | - |
| MAK07_RS10325 (2093758) | 2093758..2093979 | - | 222 | WP_001077280.1 | DUF2483 family protein | - |
| MAK07_RS10330 (2093989) | 2093989..2094249 | - | 261 | WP_000291090.1 | DUF1108 family protein | - |
| MAK07_RS10335 (2094346) | 2094346..2094507 | - | 162 | WP_000066011.1 | DUF1270 domain-containing protein | - |
| MAK07_RS10340 (2094500) | 2094500..2094721 | - | 222 | WP_000594789.1 | hypothetical protein | - |
| MAK07_RS10345 (2094792) | 2094792..2095022 | + | 231 | WP_000395455.1 | hypothetical protein | - |
| MAK07_RS10350 (2095198) | 2095198..2095938 | - | 741 | WP_001148589.1 | phage antirepressor KilAC domain-containing protein | - |
| MAK07_RS10355 (2095940) | 2095940..2096125 | - | 186 | WP_000933365.1 | helix-turn-helix transcriptional regulator | - |
| MAK07_RS10360 (2096571) | 2096571..2097053 | + | 483 | WP_000394410.1 | hypothetical protein | - |
| MAK07_RS10365 (2097154) | 2097154..2097333 | - | 180 | WP_000438352.1 | hypothetical protein | - |
| MAK07_RS10370 (2097347) | 2097347..2097583 | - | 237 | WP_001121116.1 | helix-turn-helix transcriptional regulator | - |
| MAK07_RS10375 (2097735) | 2097735..2098049 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MAK07_RS10380 (2098062) | 2098062..2098523 | + | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MAK07_RS10385 (2098707) | 2098707..2099639 | + | 933 | WP_000392183.1 | hypothetical protein | - |
| MAK07_RS10390 (2099619) | 2099619..2099798 | - | 180 | WP_000337827.1 | hypothetical protein | - |
| MAK07_RS10395 (2099911) | 2099911..2100957 | + | 1047 | WP_001145722.1 | tyrosine-type recombinase/integrase | - |
| MAK07_RS10400 (2101002) | 2101002..2102147 | + | 1146 | WP_001245443.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MAK07_RS10405 (2102407) | 2102407..2102937 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | hysA / selk | 1946529..2146601 | 200072 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T234920 WP_000525004.1 NZ_CP091875:2098062-2098523 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T234920 NZ_LR134139:c2478511-2478269 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT234920 WP_000333630.1 NZ_CP091875:2097735-2098049 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT234920 NZ_LR134139:c2478768-2478511 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |