Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2026864..2027640 Replicon chromosome
Accession NZ_CP091875
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MAK07_RS09780 Protein ID WP_000031108.1
Coordinates 2026864..2027016 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MAK07_RS09785 Protein ID WP_001251219.1
Coordinates 2027041..2027640 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK07_RS09765 (2023010) 2023010..2023831 + 822 WP_000669380.1 RluA family pseudouridine synthase -
MAK07_RS09770 (2024287) 2024287..2025672 - 1386 WP_000116227.1 class II fumarate hydratase -
MAK07_RS09775 (2025868) 2025868..2026263 - 396 WP_000901019.1 hypothetical protein -
MAK07_RS09780 (2026864) 2026864..2027016 - 153 WP_000031108.1 SAS053 family protein Toxin
MAK07_RS09785 (2027041) 2027041..2027640 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MAK07_RS09790 (2027799) 2027799..2028269 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MAK07_RS09795 (2028274) 2028274..2029401 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MAK07_RS09800 (2029552) 2029552..2030274 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MAK07_RS09805 (2030267) 2030267..2031724 - 1458 WP_000649896.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hysA / selk 1946529..2146601 200072


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T234919 WP_000031108.1 NZ_CP091875:c2027016-2026864 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T234919 NZ_LR134139:c2446967-2446860 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT234919 WP_001251219.1 NZ_CP091875:c2027640-2027041 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT234919 NZ_LR134139:2446783-2446843 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACTAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References