Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 905435..905912 Replicon chromosome
Accession NZ_CP091875
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MAK07_RS04285 Protein ID WP_000052076.1
Coordinates 905435..905623 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MAK07_RS04290 Protein ID WP_001059690.1
Coordinates 905652..905912 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAK07_RS04255 (901388) 901388..901945 + 558 WP_000824491.1 hypothetical protein -
MAK07_RS04260 (902286) 902286..902972 + 687 WP_001574556.1 thermonuclease family protein -
MAK07_RS04265 (903329) 903329..903529 + 201 WP_001059082.1 cold-shock protein -
MAK07_RS04270 (904026) 904026..904244 - 219 WP_000005879.1 hypothetical protein -
MAK07_RS04275 (904306) 904306..904590 - 285 WP_001004401.1 hypothetical protein -
MAK07_RS04280 (904678) 904678..905247 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
MAK07_RS04285 (905435) 905435..905623 - 189 WP_000052076.1 hypothetical protein Toxin
MAK07_RS04290 (905652) 905652..905912 - 261 WP_001059690.1 hypothetical protein Antitoxin
MAK07_RS04295 (906253) 906253..906456 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MAK07_RS04300 (906453) 906453..906689 - 237 WP_000368687.1 hypothetical protein -
MAK07_RS04305 (906914) 906914..907495 + 582 WP_001140696.1 histidine phosphatase family protein -
MAK07_RS04310 (907568) 907568..908185 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
MAK07_RS04315 (908341) 908341..908835 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MAK07_RS04320 (909234) 909234..909656 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
MAK07_RS04325 (909804) 909804..910520 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T234912 WP_000052076.1 NZ_CP091875:c905623-905435 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T234912 NZ_LR134139:c830098-829910 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT234912 WP_001059690.1 NZ_CP091875:c905912-905652 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT234912 NZ_LR134139:c830387-830127 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References