Detailed information of TA system TA023490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 938259..939496
• Replicon: chromosome
• Accession: NC_011900
• Organism: Streptococcus pneumoniae ATCC 700669

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: C1CE39
• Locus tag: SPN23F_RS04950
• Protein ID: WP_000405356.1
• Coordinates: 938735..939496 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: SPN23F_RS04945
• Protein ID: WP_000579605.1
• Coordinates: 938259..938735 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPN23F_RS04920	933332..934186	+	855	WP_000900020.1	ADP-ribosylglycohydrolase family protein	-
SPN23F_RS04925	934298..935182	+	885	WP_000710119.1	diacylglycerol kinase family lipid kinase	-
SPN23F_RS04930	935345..937084	+	1740	WP_000423450.1	glycoside hydrolase family 13 protein	-
SPN23F_RS04935	937170..937487	+	318	WP_000995820.1	hypothetical protein	-
SPN23F_RS04940	937533..937814	+	282	WP_000266233.1	hypothetical protein	-
SPN23F_RS04945	938259..938735	+	477	WP_000579605.1	helix-turn-helix domain-containing protein	Antitoxin
SPN23F_RS04950	938735..939496	+	762	WP_000405356.1	zeta toxin family protein	Toxin
SPN23F_RS04955	939524..940680	+	1157	Protein_937	hypothetical protein	-
SPN23F_RS04965	941512..941871	+	360	WP_000529543.1	hypothetical protein	-
SPN23F_RS04970	941881..942210	+	330	WP_000263037.1	MobC family plasmid mobilization relaxosome protein	-
SPN23F_RS13630	942233..944118	+	1886	Protein_940	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	923004..950295	27291

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29078.11 Da
• Isoelectric Point: 7.1307

>T23490 WP_000405356.1 NC_011900:938735-939496 [Streptococcus pneumoniae ATCC 700669]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELFFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T23490 NC_011900:938735-939496 [Streptococcus pneumoniae ATCC 700669]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACAATTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTATTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18270.70 Da
• Isoelectric Point: 4.5673

>AT23490 WP_000579605.1 NC_011900:938259-938735 [Streptococcus pneumoniae ATCC 700669]
MIGKNIKSLRKTHDLTQHEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGENKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT23490 NC_011900:938259-938735 [Streptococcus pneumoniae ATCC 700669]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATCGTAGGAGAAAATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGCTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTTTCTGATTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4J1TI62