Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1696162..1696724 Replicon chromosome
Accession NZ_CP091855
Organism Gordonia amicalis strain CEGA1

Toxin (Protein)


Gene name relE Uniprot ID A0A290XKJ4
Locus tag IHQ52_RS07835 Protein ID WP_006438782.1
Coordinates 1696162..1696452 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7J5WZ76
Locus tag IHQ52_RS07840 Protein ID WP_006438783.1
Coordinates 1696449..1696724 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHQ52_RS07815 (IHQ52_07815) 1691901..1692305 + 405 WP_006438776.1 SCP2 sterol-binding domain-containing protein -
IHQ52_RS07820 (IHQ52_07820) 1692340..1693972 + 1633 Protein_1549 long-chain fatty acid--CoA ligase -
IHQ52_RS07825 (IHQ52_07825) 1694842..1695312 - 471 WP_006438780.1 hypothetical protein -
IHQ52_RS07830 (IHQ52_07830) 1695974..1696165 + 192 WP_006438781.1 hypothetical protein -
IHQ52_RS07835 (IHQ52_07835) 1696162..1696452 - 291 WP_006438782.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHQ52_RS07840 (IHQ52_07840) 1696449..1696724 - 276 WP_006438783.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IHQ52_RS07845 (IHQ52_07845) 1697231..1697491 + 261 WP_232513111.1 DUF5313 family protein -
IHQ52_RS07850 (IHQ52_07850) 1697413..1698624 - 1212 Protein_1555 IS256 family transposase -
IHQ52_RS07855 (IHQ52_07855) 1698623..1699649 + 1027 Protein_1556 IS481 family transposase -
IHQ52_RS07860 (IHQ52_07860) 1700119..1701177 - 1059 WP_024498687.1 AraC family transcriptional regulator -
IHQ52_RS07865 (IHQ52_07865) 1701296..1701445 + 150 Protein_1558 2Fe-2S iron-sulfur cluster-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10789.30 Da        Isoelectric Point: 11.1310

>T234897 WP_006438782.1 NZ_CP091855:c1696452-1696162 [Gordonia amicalis]
MSDAPTDSPAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRNDLAGLHSARRGDYRVLLRIDDPNH
TIVVVRIDHRAHAYRT

Download         Length: 291 bp

>T234897 NZ_LR134117:267183-267518 [Serratia odorifera]
ATGAAAACCCTCGACAAAATACCCCGCATCACGCCCAGCGCCAACCAAGCACGAACTGAATACCAGCAACTACTCGCCTG
GTTGCTAGCTCACTGTTACGGTCTGGAACTCAACGATACGCCGTATCACGACGAACAGGCTATTGCCAAACAGATTGAGC
ATGGCATCACGGTAAGGGAAACCGTCAACGAACTGGTGGAGAAATTTGACTTGGTACGCATTGATCGCCCCGGTTTCAGC
CTGATGGCACAAGACCCGCTGTTGAACGGTGGGGATATGTTACGCGCCCGCAGTGCGCTGGGTTTGCGAAGCCCGGTCAA
TCGTCGCCTCACCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9740.91 Da        Isoelectric Point: 4.6221

>AT234897 WP_006438783.1 NZ_CP091855:c1696724-1696449 [Gordonia amicalis]
MTTVPLGEAKDKLSALVDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGHTVSID
DLRAEHGMPPK

Download         Length: 276 bp

>AT234897 NZ_LR134117:267594-267965 [Serratia odorifera]
ATGAAAGACACCGATAACCAGACAAACCTGAATACCCACAACGACATCACCCCGATCTGGGGCCTGCAATCCGCTATCAC
GCCACGCCTGGGAGCCAGGTTGGTCCAGCAGGGTAATCACCTGCATTTTCTAGCTGACCGAGCTGGTTTGGTTGGCACAT
TCGATTCTGATGCTCTCCAAATGCTTGATACCGCTTTTCCTGTGTTGATTGAGCAGTTGGAGGTCCGGTTGCGCTCCGGT
GAGCTAGATCAGCGTCGTCAGCATTGCGTCACTGTCCAGCATGCTGGCTTTACCTGTGAAGCGGATACGTTGGGCAGTTT
TGGCCATGTCTATATTGCGGTCTATCAAACGACACCGTCCAACACGGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290XKJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7J5WZ76

References