234894

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5225841..5226466 Replicon chromosome
Accession NZ_CP091846
Organism Klebsiella pneumoniae strain NB05

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag L7D54_RS25565 Protein ID WP_002882817.1
Coordinates 5225841..5226224 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag L7D54_RS25570 Protein ID WP_004150355.1
Coordinates 5226224..5226466 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7D54_RS25550 5223207..5224109 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
L7D54_RS25555 5224106..5224741 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
L7D54_RS25560 5224738..5225667 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
L7D54_RS25565 5225841..5226224 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
L7D54_RS25570 5226224..5226466 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
L7D54_RS25575 5226671..5227588 + 918 WP_002882812.1 alpha/beta hydrolase -
L7D54_RS25580 5227602..5228543 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
L7D54_RS25585 5228588..5229025 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
L7D54_RS25590 5229022..5229882 - 861 WP_002882807.1 virulence factor BrkB family protein -
L7D54_RS25595 5229876..5230475 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T234894 WP_002882817.1 NZ_CP091846:c5226224-5225841 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T234894 NZ_LR134117:30363-30761 [Serratia odorifera]
ATGTTGAAGTACCTGCTGGACACCAACACGTGCATTTTCACCATCAAGAACAAACCCACACTCGTCAGGGAGCGTTTCAA
CCTGAATACCTCTCGCCTGTGCATCAGCTCGGTTACCCTGATGGAACTGATTTACGGCGCGGAAAAGAGCCAGGCGCCGG
AACGTAACCTTGCGGTGCTCGAGGGGTTCATCGCGCGTCTCGACGTTCTGAACTACGATGCCGCAGCTGCCGCACACAGC
GGTCAAATTCGGGCCGAATTGAGCCGACAGGGTCTCCCTATCGGTCCCTTTGACCTGATGATCGCCGGACATGCCCGCAG
CCAGGGGCTGATTGTAGTCACCAACAACACGCGGGAATTTGAGCGTGTTGACGGGTTGCGTATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT234894 WP_004150355.1 NZ_CP091846:c5226466-5226224 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT234894 NZ_LR134117:30136-30363 [Serratia odorifera]
ATGGAAACAACCGTTTTCCTCAGTAACCGCAGCCAGGCCGTTCGGCTACCGAAGGCCGTGGCGTTGCCTGAAGACGTGAA
ACGTGTGGAGGTCATCGCTGTGGGTCGTAGCCGCATCATCACGCCAGCCGGTGAGGGCTGGGACAACTGGTTCGAGGGTG
AAAATGTCAGCGCCGATTTCATGACGTCGCGCGACCAACCCCCGATGCAAGAGCGGGAGGCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References