Detailed information of TA system TA234893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4901790..4903471
• Replicon: chromosome
• Accession: NZ_CP091846
• Organism: Klebsiella pneumoniae strain NB05

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: L7D54_RS24060
• Protein ID: WP_002885155.1
• Coordinates: 4901790..4902707 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: L7D54_RS24065
• Protein ID: WP_004151732.1
• Coordinates: 4902713..4903471 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L7D54_RS24040	4897096..4898616	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
L7D54_RS24045	4898613..4899611	+	999	WP_002885172.1	ribose ABC transporter permease	-
L7D54_RS24050	4899642..4900583	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
L7D54_RS24055	4900658..4901665	+	1008	WP_004151731.1	carbohydrate kinase family protein	-
L7D54_RS24060	4901790..4902707	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
L7D54_RS24065	4902713..4903471	-	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
L7D54_RS24070	4903557..4904285	-	729	WP_002885152.1	response regulator transcription factor	-
L7D54_RS24075	4904558..4906705	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
L7D54_RS24080	4906935..4907621	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T234893 WP_002885155.1 NZ_CP091846:c4902707-4901790 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T234893 NZ_LR134116:4618362-4618652 [Yersinia intermedia]
ATGCCAAGGACGGCAGATTATACCAAAGACTTCCTTAAAGACTGGGAAAGGCTGTCCCGCAGTGGTCGTTATGATATGTA
TCGACTCAAACATGCCATGTTACTGCTTATTGCAAATGATACGCCGTTAGGTGCCGAATGGTTAGACCATCCACTTAAAG
GAGACTGGGAAAATTTCCGAGAATGCCATATCGGAGGAGATTTTTTACTGATCTATAAATTAAGTAGCAGCAGTAAAATA
AGCCAGATTATCTTTGTTCGCGCAGGCACCCACTCAGAACTGTTTGATTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT234893 WP_004151732.1 NZ_CP091846:c4903471-4902713 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT234893 NZ_LR134116:4618070-4618351 [Yersinia intermedia]
ATGGCTACACACACCACAATGTTGCATGTCCGTATTGATGATGACGTCAAAAAACAGGCAACAGCAGCACTCAATGCAAT
GGGCCTTTCGGTTTCCGACGCTGTGCGTTTATTTTTAAATCGCGTCGTCGCTGATCAGGCATTTCCATTCGAATTGAAAG
TACCTAACCCCCAGACTCGTGCGGCGATGCAGGAAGCAGAAGAGATAGTTCAAGCCCATAGCGCACGTTTTACTACTTCG
GATGAGTTATTTATTGAACTTGAAAAAGACAACAGTAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5