Detailed information of TA system TA234890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 4030942..4031561
• Replicon: chromosome
• Accession: NZ_CP091846
• Organism: Klebsiella pneumoniae strain NB05

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: R8WYV2
• Locus tag: L7D54_RS19835
• Protein ID: WP_002892050.1
• Coordinates: 4031343..4031561 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: J2DPF6
• Locus tag: L7D54_RS19830
• Protein ID: WP_002892066.1
• Coordinates: 4030942..4031316 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L7D54_RS19820	4026094..4027287	+	1194	WP_002892072.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
L7D54_RS19825	4027310..4030456	+	3147	WP_002892069.1	multidrug efflux RND transporter permease subunit AcrB	-
L7D54_RS19830	4030942..4031316	+	375	WP_002892066.1	Hha toxicity modulator TomB	Antitoxin
L7D54_RS19835	4031343..4031561	+	219	WP_002892050.1	HHA domain-containing protein	Toxin
L7D54_RS19840	4031720..4032286	+	567	WP_002892030.1	maltose O-acetyltransferase	-
L7D54_RS19845	4032258..4032398	-	141	WP_004147370.1	hypothetical protein	-
L7D54_RS19850	4032419..4032889	+	471	WP_002892026.1	YlaC family protein	-
L7D54_RS19855	4032864..4034315	-	1452	WP_002892023.1	PLP-dependent aminotransferase family protein	-
L7D54_RS19860	4034416..4035114	+	699	WP_002892021.1	GNAT family protein	-
L7D54_RS19865	4035111..4035251	-	141	WP_002892018.1	type B 50S ribosomal protein L36	-
L7D54_RS19870	4035251..4035514	-	264	WP_002892011.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8628.00 Da
• Isoelectric Point: 8.9008

>T234890 WP_002892050.1 NZ_CP091846:4031343-4031561 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Nucleotide

• Length: 219 bp

>T234890 NZ_LR134116:c2254106-2253648 [Yersinia intermedia]
ATGATGCTTTATCGCATCGTGATGCGCCGCTACCTGGCTTCAACCTGGACCGGTTATGGCGCTGAAATCTATGGTGGGCG
CTGGAATCATAAAGGCCACGCCGCCATCTATTTAGCCAGTAGTGTGTCACTGGCGATGCTGGAAACACTGGTACATATTC
AAGACAGCTCAACACTCAGCGAGTTTGAGTTATTCCAGATTGAGATTGATGACAGCAATATCATGCTGTTACAACCACAG
GATTGGCCACTGGACTGGCGCAATGACCCCGCGCCTGCGGCTACGATGGATATCGGCACAGAGTGGCTGGAATCAGAATC
ATCAATTGGATTGCTGGTCCCATCCACACTGGTGCCTTCAGAACATAATATGCTGGTCAATCCGCGCCACAAAGATTTTC
AGGCCTGCTTGAGTACCGCCAAAGCACTCTCCTTTGCCTTCGATCCCCGATTGAAATAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14368.06 Da
• Isoelectric Point: 4.8989

>AT234890 WP_002892066.1 NZ_CP091846:4030942-4031316 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Nucleotide

• Length: 375 bp

>AT234890 NZ_LR134116:c2254638-2254192 [Yersinia intermedia]
ATGAGAGCTTATCAACCTACCCCCACAACGAAAGCAGGGGCACTCTGGCGAGAAATTGGTTTGCCAGCCAGCCGTGGCAC
GGTATTAGTCGACAGCATCAAGCTGGGTTTTTCTGTCGATGTCATCGACAGTATCCATCTTTGGGCCTCTATGCCTAAAT
CTGAAATATTGCGCGCTACCGGTATTCCCAGCCGTAGCCTGACCCGCCGACGCACCCATGATGGCCGTTTTACACCAGAA
GAGAGTGAGCGAATCGCGCGCTTCGTGCGGGTAATGGATGCCGCAGTTGACCTCTTCGGTGGTGATAAAGGCAAAGCTAT
CGTCTGGATGTCGACACCCATTAAGGGGCTTGGGCACCGCAGTCCTGACTCACTGCTGGAGACCGAAACCGGCGCGTTAG
AAATCTGCGATTTAATTGGGCGGCTGGAACACGGTGTATTTTCATAG

Structures

Toxin

• AlphaFold DB: A0A2P8K6F2

Antitoxin

• AlphaFold DB: A0A0H3GJ93