234881

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874230..874887 Replicon chromosome
Accession NZ_CP091846
Organism Klebsiella pneumoniae strain NB05

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L7D54_RS04420 Protein ID WP_002916310.1
Coordinates 874477..874887 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L7D54_RS04415 Protein ID WP_002916312.1
Coordinates 874230..874496 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7D54_RS04390 869386..870819 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L7D54_RS04395 870938..871666 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L7D54_RS04400 871716..872027 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
L7D54_RS04405 872191..872850 + 660 WP_002916317.1 hemolysin III family protein -
L7D54_RS04410 873001..873984 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L7D54_RS04415 874230..874496 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L7D54_RS04420 874477..874887 + 411 WP_002916310.1 protein YgfX Toxin
L7D54_RS04425 874894..875415 - 522 WP_002916308.1 flavodoxin FldB -
L7D54_RS04430 875516..876412 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L7D54_RS04435 876435..877148 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L7D54_RS04440 877154..878887 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T234881 WP_002916310.1 NZ_CP091846:874477-874887 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T234881 NZ_LR134108:c1678-1493 [Enterococcus faecium]
ATGCCACTTACGGGAAAAGAAATGCTTAAGTTATTGAAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATCTCATCA
TCATCTTTATAAGGATGGTGTTAGAATCACTGTTCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGCGAAAAA
TTTTGAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT234881 WP_002916312.1 NZ_CP091846:874230-874496 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234881 NZ_LR134108:c1459-1028 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGGATTGCTATGGCACAAGAGGTGTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGATCTACTTCCAGAACCAACACCAATCAATAAGATTTCTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGTTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References